PLASMA CLEARANCE OF CORTISOL AS A FUNCTION OF PLASMA CORTISOL LEVELS IN NORMAL AND OBESE PERSONS AND IN PATIENTS WITH URAEMIA OR CIRRHOSIS OF THE LIVER
| Autor: | K. A. Deck, H. Hillen, P. Baur |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Liver Cirrhosis Male endocrine system medicine.medical_specialty Cirrhosis Hydrocortisone Endocrinology Diabetes and Metabolism Plasma flow Endocrinology Transcortin Internal medicine Humans Medicine Infusions Parenteral In patient Obesity Uremia Plasma clearance biology business.industry Liver cell General Medicine Metabolism Middle Aged medicine.disease Plasma cortisol biology.protein business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta Endocrinologica. 91:122-133 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0910122 |
| Popis: | Plasma cortisol levels in 2 normal persons, 2 obese persons, 2 uraemic patients, and 2 patients with cirrhosis of the liver were raised in 4 steps by a combination of iv priming doses and continuous infusions of cortisol. Plasma cortisol levels and transcortin binding were measured as well as plasma clearance rates of labelled and unlabelled cortisol during each of the 5 experimental periods. Plasma cortisol levels increased less and plasma clearance rates of labelled and unlabelled cortisol increased more in obese persons than in normal persons; in patients with disturbed metabolism of cortisol (uraemia, cirrhosis of the liver) the reverse is true. Plasma clearance rates of free cortisol were calculated and differed from an estimated hepatic plasma flow of 0.7 1/min under certain conditions. Since free cortisol is metabolized faster than transcortin-bound cortisol, increasing plasma clearance rates of cortisol are probably due to increasing ratios free/bound cortisol when total plasma cortisol levels are raised. Low plasma clearance rates of cortisol in uraemia and cirrhosis of the liver are thought to be due to endproduct inhibition, respectively reduced liver cell mass. |
| Databáze: | OpenAIRE |
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