Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates
| Autor: | Andrew Bartholomaeus, Jackson Thomas, Wubshet Tesfaye, Solomon Abrha |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Drug medicine.medical_specialty Investigational drug Impetigo mice medicine.drug_class media_common.quotation_subject 030106 microbiology Antibiotics impetigo review Skin infection medicine.disease_cause Biochemistry Microbiology 03 medical and health sciences In vivo medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics skin and connective tissue diseases media_common integumentary system business.industry lcsh:RM1-950 hamsters Antimicrobial medicine.disease in vivo evaluation Dermatology animal models skin infections topical treatment 030104 developmental biology Infectious Diseases lcsh:Therapeutics. Pharmacology Staphylococcus aureus business |
| Zdroj: | Antibiotics, Vol 9, Iss 694, p 694 (2020) Antibiotics |
| ISSN: | 2079-6382 |
| Popis: | Impetigo (school sores), a superficial skin infection commonly seen in children, is caused by the gram-positive bacteria Staphylococcus aureus and/or Streptococcus pyogenes. Antibiotic treatments, often topical, are used as the first-line therapy for impetigo. The efficacy of potential new antimicrobial compounds is first tested in in vitro studies and, if effective, followed by in vivo studies using animal models and/or humans. Animal models are critical means for investigating potential therapeutics and characterizing their safety profile prior to human trials. Although several reviews of animal models for skin infections have been published, there is a lack of a comprehensive review of animal models simulating impetigo for the selection of therapeutic drug candidates. This review critically examines the existing animal models for impetigo and their feasibility for testing the in vivo efficacy of topical treatments for impetigo and other superficial bacterial skin infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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