Brain State-dependent Gain Modulation of Corticospinal Output in the Active Motor System
| Autor: | Ulf Ziemann, Georgios Naros, Alireza Gharabaghi, Maria Teresa Leão, Tobias Lehnertz |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cognitive Neuroscience medicine.medical_treatment Pyramidal Tracts Context (language use) Cellular and Molecular Neuroscience Young Adult Rhythm Motor system medicine Coherence (signal processing) Humans Muscle Skeletal Brain–computer interface Physics Electromyography Motor Cortex Electroencephalography Evoked Potentials Motor Transcranial Magnetic Stimulation Transcranial magnetic stimulation medicine.anatomical_structure Modulation Brain-Computer Interfaces Cortical Excitability Female Neuroscience Motor cortex |
| Zdroj: | Cerebral cortex (New York, N.Y. : 1991). 30(1) |
| ISSN: | 1460-2199 |
| Popis: | The communication through coherence hypothesis suggests that only coherently oscillating neuronal groups can interact effectively and predicts an intrinsic response modulation along the oscillatory rhythm. For the motor cortex (MC) at rest, the oscillatory cycle has been shown to determine the brain’s responsiveness to external stimuli. For the active MC, however, the demonstration of such a phase-specific modulation of corticospinal excitability (CSE) along the rhythm cycle is still missing. Motor evoked potentials in response to transcranial magnetic stimulation (TMS) over the MC were used to probe the effect of cortical oscillations on CSE during several motor conditions. A brain–machine interface (BMI) with a robotic hand orthosis allowed investigating effects of cortical activity on CSE without the confounding effects of voluntary muscle activation. Only this BMI approach (and not active or passive hand opening alone) revealed a frequency- and phase-specific cortical modulation of CSE by sensorimotor beta-band activity that peaked once per oscillatory cycle and was independent of muscle activity. The active MC follows an intrinsic response modulation in accordance with the communication through coherence hypothesis. Furthermore, the BMI approach may facilitate and strengthen effective corticospinal communication in a therapeutic context, for example, when voluntary hand opening is no longer possible after stroke. |
| Databáze: | OpenAIRE |
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