Blood morphology and the levels of selected cytokines related to hematopoiesis in occupational short-term exposure to lead
| Autor: | Zenon P. Czuba, Edyta Hudziec, Marta Boroń, Michał Dobrakowski, Ewa Birkner, Artur Chwalba, Sławomir Kasperczyk |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Blood Platelets Male Air Pollutants Occupational 010501 environmental sciences Toxicology 01 natural sciences Andrology 03 medical and health sciences Hemoglobins Occupational Exposure Leukocytes Medicine Humans Platelet Lead (electronics) 0105 earth and related environmental sciences Pharmacology Hematologic Tests medicine.diagnostic_test business.industry Decreased hemoglobin Middle Aged Hematopoiesis Haematopoiesis 030104 developmental biology Lead Immunology Population study Cytokines Blood lead level Hemoglobin Occupational exposure business |
| Zdroj: | Toxicology and applied pharmacology. 305 |
| ISSN: | 1096-0333 |
| Popis: | The aim of the study was to investigate the influence of a short-term exposure to lead on the blood morphology and the levels of selected cytokines related to hematopoiesis in occupationally exposed workers. The study population included 37 males occupationally exposed to lead for 36 to 44days. Their blood lead level raised from 10.7±7.67μg/dl at baseline to the level of 49.1±14.1μg/dl at the end of the study. The level of hemoglobin and values of MCH and MCHC were decreased due to a short-term exposure to lead by 2%, 2%, and 1%, respectively. The counts of WBC, LYM, and MXD increased significantly by 5%, 7%, and 35%. Similarly, the count of PLT increased by 7%, while PDW, MPV, and P-LCR decreased by 6%, 3%, and 9%, respectively. The levels of IL-7, G-CSF, HGF, PDGF AB/BB, SCF, and PECAM-1, decreased significantly by 30%, 33%, 8%, 30%, 25%, and 20%, respectively. A short-term occupational exposure to lead results in a decreased hemoglobin level and increased counts of WBC and PLT. Changes in counts and proportions of different types of leukocytes and decreased values of PLT indices, such as PDW, MPV, and P-LCR, due to the subacute lead-exposure may be associated with lead-induced decreased levels of cytokines related to hematopoiesis, including SCF, G-CSF, IL-7, and PDGF. |
| Databáze: | OpenAIRE |
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