Association Between Bronchiectasis, Systemic Inflammation, and Tumor Necrosis Factor α
| Autor: | Pilar Román-Sánchez, Juan José Soler-Cataluña, Miquel Perpiñá-Tordera, Martín Yago, Miguel Ángel Martínez-García, María José Pastor, Arturo Carratalá |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Pathology Inflammation Systemic inflammation medicine.disease_cause Gastroenterology Cystic fibrosis Internal medicine medicine Humans Aged Bronchiectasis medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Pseudomonas aeruginosa General Medicine medicine.disease Respiratory failure Erythrocyte sedimentation rate Female Tumor necrosis factor alpha medicine.symptom business Biomarkers |
| Zdroj: | Archivos de Bronconeumología ((English Edition)). 44:8-14 |
| ISSN: | 1579-2129 |
| DOI: | 10.1016/s1579-2129(08)60003-8 |
| Popis: | Objective The relationship between systemic inflammation and different measures of bronchiectasis severity has not been described. The objective of this study was to analyze the relationship between plasma concentrations of tumor necrosis factorα (TNF-α), as a marker of systemic inflammation, and some commonly used criteria for quantifying bronchiectasis severity in clinically stable patients whose disease was not caused by cystic fibrosis. Patients and methods Sixty-eight clinically stable patients with bronchiectasis and 19 age- and sex-matched healthy control subjects were included in the study. Data on disease history, symptoms, severity, functional variables, sputum volume, and microbiological cultures, laboratory findings, and other indicators of disease course were collected. Plasma concentrations of TNF-α were measured using high-resolution enzyme-linked immunosorbent assay. Results Plasma concentrations of TNF-α were higher in patients than controls (8.28 vs 5.67 pg/mL; P=.001). This observation correlated with other markers of systemic inflammation such as erythrocyte sedimentation rate (r=0.42; P=.001), C-reactive protein (r=0.45; P=.001), and percentage of peripheral blood neutrophils (r=0.45; P=.001). Patients with high plasma concentrations of TNF-α (>8.1 pg/dL) had more severe disease (5.19 vs 3.21; P=.001), were more likely to have respiratory failure (37.5% vs 8.3%; P=.003), and a higher rate of Pseudomonas aeruginosa colonization (34.3% vs 8.3%; P=.008). Conclusions High plasma concentrations of TNF-α were associated with several criteria usually used to assess severity of bronchiectasis in clinically stable patients with disease not caused by cystic fibrosis. |
| Databáze: | OpenAIRE |
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