EFFECTS OF SUCRALFATE, CIMETIDINE AND RABEPRAZOLE ON MUCOSAL HYDROXYPROLINE CONTENT IN HEALING OF ETHANOL-HCL-INDUCED GASTRIC LESIONS
| Autor: | Masakatsu Nakamura, Masahiko Nakamura, Tomoyuki Shibata, Tomiyasu Arisawa, Masao Harata, Tamaki Mizuno, Hiroshi Nakano, Hiroshi Fujita, Tomomitsu Tahara, Mitsuo Nagasaka, Yoshiji Ohta, Shin Hasegawa, Yoshio Kamiya |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Physiology Sucralfate Procollagen-Proline Dioxygenase Rabeprazole Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Rats Sprague-Dawley Lesion Hydroxyproline chemistry.chemical_compound Physiology (medical) Internal medicine medicine Gastric mucosa Animals Stomach Ulcer Cimetidine Pharmacology Ethanol business.industry Stomach Anti-ulcer Agent Anti-Ulcer Agents Rats medicine.anatomical_structure chemistry Gastric Mucosa Hydrochloric Acid medicine.symptom business medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 33:628-632 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.2006.04418.x |
| Popis: | 1. No general consensus has been reached on the treatment of acute gastric lesions. The aims of the present study were to clarify the effects of sucralfate, cimetidine and rabeprazole monotherapies and combination therapies on acute gastric lesions from the viewpoint of connective tissue regeneration. 2. Gastric lesions were experimentally created by the oral administration of 50% ethanol-0.15 mol/L HCl to rats. After 30 min, the anti-ulcer agents sucralfate (100 mg/kg), cimetidine (20 mg/kg) and rabeprazole (2 mg/kg) were administered separately or in combination and the stomach was excised at different times to measure the level of hydroxyproline in the gastric mucosa and determine lesion index. Immunostaining against prolylhydroxylase was performed on some specimens. 3. In the control group, lesion index decreased linearly from 30 min after ethanol-HCl administration and the level of mucosal hydroxyproline peaked between 2 and 4 h later. Although sucralfate significantly promoted lesion healing, it had no effect on mucosal hydroxyproline level. Cimetidine suppressed increases in mucosal hydroxyproline and prolonged lesion healing, but these findings were reversed by combining cimetidine and sucralfate. Rabeprazole had no significant effect on lesion healing, but promoted lesion healing in combination with sucralfate. Immunohistochemical analysis showed that prolylhydroxylase was expressed in spindle cells that lined the glandular cells in a boundary area between normal and injured tissues. 4. Under conditions in which the effects of intragastric pH are minimal, sucralfate is superior to antisecretory agents in promoting the healing of acute gastric lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|