An assessment of false positive rates for malaria rapid diagnostic tests caused by non-Plasmodium infectious agents and immunological factors

Autor: David Bell, Peter L. Chiodini, Iveth J. González, Jane Cunningham, Qin Cheng, Michelle L. Gatton, Sadmir Ciketic, John W. Barnwell, Sandra Incardona
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Plasmodium
Physiology
Plasmodium vivax
lcsh:Medicine
Biochemistry
Dengue fever
Dengue
0302 clinical medicine
Zoonoses
Immune Physiology
Medicine and Health Sciences
Schistosomiasis
Medicine
African trypanosomiasis
030212 general & internal medicine
lcsh:Science
Leishmaniasis
Cross Reactivity
Rapid diagnostic test
Immune System Proteins
Multidisciplinary
biology
Body Fluids
Infectious Diseases
Blood
Helminth Infections
Anatomy
Research Article
Neglected Tropical Diseases
Immunology
030231 tropical medicine
Antigens
Protozoan
Sensitivity and Specificity
Antibodies
Blood Plasma
03 medical and health sciences
Diagnostic Medicine
Parasite Groups
parasitic diseases
Parasitic Diseases
Humans
Rheumatoid factor
Chagas Disease
False Positive Reactions
Protozoan Infections
Diagnostic Tests
Routine
business.industry
lcsh:R
Reproducibility of Results
Biology and Life Sciences
Proteins
Tropical Diseases
biology.organism_classification
medicine.disease
Malaria
Immune System
Parasitology
lcsh:Q
business
Apicomplexa
Trypanosomiasis
Zdroj: PLoS ONE, Vol 13, Iss 5, p e0197395 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Background Malaria rapid diagnostic tests (RDTs) can produce false positive (FP) results in patients with human African trypanosomiasis and rheumatoid factor (RF), but specificity against other infectious agents and immunological factors is largely unknown. Low diagnostic specificity caused by cross-reactivity may lead to over-estimates of the number of malaria cases and over-use of antimalarial drugs, at the cost of not diagnosing and treating the true underlying condition. Methods Data from the WHO Malaria RDT Product Testing Programme was analysed to assess FP rates of 221 RDTs against four infectious agents (Chagas, dengue, Leishmaniasis and Schistosomiasis) and four immunological factors (anti-nuclear antibody, human anti-mouse antibody (HAMA), RF and rapid plasma regain). Only RDTs with a FP rate against clean negative samples less than 10% were included. Paired t-tests were used to compare product-specific FP rates on clean negative samples and samples containing non-Plasmodium infectious agents and immunological factors. Results Forty (18%) RDTs showed no FP results against any tested infectious agent or immunological factor. In the remaining RDTs significant and clinically relevant increases in FP rates were observed for samples containing HAMA and RF (P
Databáze: OpenAIRE
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