Systematic review and meta-analysis of dietary carbohydrate restriction in patients with type 2 diabetes
| Autor: | Arne Astrup, Ole Snorgaard, Grith M. Poulsen, Henning K Andersen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Carbohydrate(s) 030209 endocrinology & metabolism Glycemic Control Type 2 diabetes Cochrane Library law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Diabetes mellitus medicine 030212 general & internal medicine Medical nutrition therapy Glycemic Dietary Intervention business.industry Clinical Care/Education/Nutrition/Psychosocial Research Carbohydrate medicine.disease Type 2 Diabetes Endocrinology Glycemic index business |
| Zdroj: | Snorgaard, O, Møller, G, Andersen, H K & Astrup, A 2017, ' Systematic review and meta-analysis of dietary carbohydrate restriction in patients with type 2 diabetes ', B M J Open Diabetes Research & Care, vol. 5, e000354 . https://doi.org/10.1136/bmjdrc-2016-000354 BMJ Open Diabetes Research & Care |
| DOI: | 10.1136/bmjdrc-2016-000354 |
| Popis: | Objective: Nutrition therapy is an integral part of selfmanagement education in patients with type 2 diabetes. Carbohydrates with a low glycemic index arerecommended, but the ideal amount of carbohydrate in the diet is unclear. We performed a meta-analysis comparing diets containing low to moderate amountsof carbohydrate (LCD) (energy percentage below 45%) to diets containing high amounts of carbohydrate (HCD) in subjects with type 2 diabetes.Research design and methods: We systematically reviewed Cochrane library databases, EMBASE, and MEDLINE in the period 2004–2014 for guidelines,meta-analyses, and randomized trials assessing the outcomes HbA1c, BMI, weight, LDL cholesterol, quality of life (QoL), and attrition.Results: We identified 10 randomized trials comprising 1376 participants in total. In the first year of intervention, LCD was followed by a 0.34% lower HbA1c (3.7 mmol/mol) compared with HCD (95% CI 0.06 (0.7 mmol/mol), 0.63 (6.9 mmol/mol)). The greater the carbohydrate restriction, the greater theglucose-lowering effect (R=−0.85, pweight, LDL cholesterol, QoL, and attrition rate was similar throughout interventions.Limitations: Glucose-lowering medication, the nutrition therapy, the amount of carbohydrate in the diet, glycemic index, fat and protein intake, baseline HbA1c, and adherence to the prescribed diets could all have affected the outcomes.Conclusions: Low to moderate carbohydrate diets have greater effect on glycemic control in type 2 diabetes compared with high-carbohydrate diets in the first year of intervention. The greater the carbohydrate restriction, the greater glucose lowering, a relationship that has not been demonstrated earlier. Apart from thislowering of HbA1c over the short term, there is no superiority of low-carbohydrate diets in terms of glycemic control, weight, or LDL cholesterol. |
| Databáze: | OpenAIRE |
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