Polygenic control of the expression of biological activities of an antitumor polysaccharide, lentinan

Autor:	Yukiko Y. Maeda, Sumiyo Takahama, Yuki Kohara, Hiromichi Yonekawa
Rok vydání:	1998
Předmět:	Pharmacology Genetic Linkage Immunology Genes MHC Class II Chromosome Mapping Antineoplastic Agents Genes Recessive Hemorrhage Mice Inbred Strains Vasodilation Mice Lentinan Species Specificity Animals Hypersensitivity Delayed Acute-Phase Reaction Genes Dominant
Zdroj:	International journal of immunopharmacology. 19(9-10)
ISSN:	0192-0561
Popis:	Genetic studies were carried out on two in vivo responses of lentinan, delayed type-acute phase responses (DT-APR) and vascular dilation and hemorrhage (VDH). Linkage analyses showed that DT-APR was controlled by two recessive genes, ltnr1 and ltnr2, which were mapped on chromosome 3 and 11, respectively. VDH was also found to be controlled by polygenes. One dominant major gene, Ltnr3, and three dominant minor genes, Ltnr4, Ltnr5, and Ltnr6, were mapped on chromosomes 6, 9, 15 and 16, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcddb2b28193534bef817025906893b5 https://pubmed.ncbi.nlm.nih.gov/9637340 Zobrazit plný text záznamu Full Text from ScienceDirect