A review of epigenetic regulation in wound healing: Implications for the future of wound care
| Autor: | Fiona M. Wood, Christopher J. Lewis, Andrew W. Stevenson, Mark W. Fear |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Keratinocytes
Dermatology Chromatin remodeling Epigenesis Genetic Histones 030207 dermatology & venereal diseases 03 medical and health sciences Wound care 0302 clinical medicine Animals Humans Epigenetics Skin Skin repair Wound Healing biology DNA Methylation Fibroblasts Chromatin Histone DNA methylation biology.protein Surgery Wound healing Neuroscience |
| Zdroj: | Wound Repair and Regeneration. 28:710-718 |
| ISSN: | 1524-475X 1067-1927 |
| DOI: | 10.1111/wrr.12838 |
| Popis: | Epigenetic regulatory mechanisms are essential for maintaining skin homeostasis and aid in the processes of wound healing. The nucleus co-ordinates gene expression using epigenetic regulatory mechanisms based on distinct chromatin structural states and their remodeling. These include DNA methylation and hydroxymethylation, post-translational histone modifications, ATP-dependent chromatin remodeling and higher-order chromatin structure and 3D genome organization. Epigenetic pathways play a key role in co-ordinating the behavior and activity of the multitude of cell types seen during skin repair, and research is now focusing on how wound healing can be modulated by altering the activity of certain reparative genes. Herein, we aim to highlight recent advances in understanding epigenetic regulatory mechanisms, with particular reference to those involved in keratinocyte and fibroblast biology. We also propose future directions for exploration of epigenetic mechanisms, and their potential clinical applications in acute wound care. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |