The Nrf1 and Nrf2 Balance in Oxidative Stress Regulation and Androgen Signaling in Prostate Cancer Cells
| Autor: | Debasis Mondal, Asim B. Abdel-Mageed, Michelle A. Schultz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.drug_class androgen independence androgen receptor (AR) Review androgen deprivation therapy medicine.disease_cause urologic and male genital diseases reactive oxygen species (ROS) lcsh:RC254-282 Androgen deprivation therapy Prostate cancer Transactivation Internal medicine LNCaP Medicine oxidative stress Nrf1 (NF-E2 related factor-1) Transcription factor business.industry lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Androgen medicine.disease prostate cancer di-hydrotestosterone (DHT) Nrf2 (NF-E2 related factor-2) Endocrinology Oncology Cancer cell Cancer research business Oxidative stress |
| Zdroj: | Cancers Cancers, Vol 2, Iss 2, Pp 1354-1378 (2010) |
| ISSN: | 2072-6694 |
| Popis: | Reactive oxygen species (ROS) signaling has recently sparked a surge of interest as being the molecular underpinning for cancer cell survival, but the precise mechanisms involved have not been completely elucidated. This review covers the possible roles of two ROS-induced transcription factors, Nrf1 and Nrf2, and the antioxidant proteins peroxiredoxin-1 (Prx-1) and Thioredoxin-1 (Txn-1) in modulating AR expression and signaling in aggressive prostate cancer (PCa) cells. In androgen independent (AI) C4-2B cells, in comparison to the parental androgen dependent (AD) LNCaP cells, we present evidence of high Nrf1 and Prx-1 expression and low Nrf2 expression in these aggressive PCa cells. Furthermore, in DHT treated C4-2B cells, increased expression of the p65 (active) isoform of Nrf1 correlated with enhanced AR transactivation. Our findings implicate a crucial balance of Nrf1 and Nrf2 signaling in regulating AR activity in AI-PCa cells. Here we will discuss how understanding the mechanisms by which oxidative stress may affect AR signaling may aid in developing novel therapies for AI-PCa. |
| Databáze: | OpenAIRE |
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