Selective Changes of GABAA Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics
| Autor: | Georgy Bakalkin, Olga Kononenko, Esa R. Korpi, Igor Bazov, Zhe Jin, Bryndis Birnir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
alcohol dependence
brain Hippocampus Hippocampal formation lcsh:RC321-571 tonic inhibition GABA 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cortex (anatomy) medicine Prefrontal cortex lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry post-mortem 030304 developmental biology Original Research GABAA channel 0303 health sciences alcohol Chemistry GABAA receptor Dentate gyrus GABAA receptors Biochemistry and Molecular Biology Dorsolateral prefrontal cortex medicine.anatomical_structure Cortex GABA(A) channel Orbitofrontal cortex Neuroscience Biokemi och molekylärbiologi 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Cellular Neuroscience Frontiers in Cellular Neuroscience, Vol 5 (2012) |
| ISSN: | 1662-5102 |
| DOI: | 10.3389/fncel.2011.00030 |
| Popis: | Alcohol dependence is a common chronic relapsing disorder. The development of alcohol dependence has been associated with changes in brain GABA(A) channel-mediated neurotransmission and plasticity. We have examined mRNA expression of the GABA(A) channel subunit genes in three brain regions in individuals with or without alcohol dependence using quantitative real-time PCR assay. The levels of selective GABA(A) channel subunit mRNAs were altered in specific brain regions in alcoholic subjects. Significant increase in the α1, α4, α5, β1, and γ1 subunit mRNAs in the hippocampal dentate gyrus region, and decrease in the β2 and δ subunit mRNAs in the orbitofrontal cortex were identified whereas no changes in the dorsolateral prefrontal cortex were detected. The data increase our understanding of the role of GABA(A) channels in the development of alcohol dependence. |
| Databáze: | OpenAIRE |
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