Lipophilic versus hydrodynamic modes of uptake and release by contact lenses of active entities used in multipurpose solutions
| Autor: | Stanley W. Huth, Lisa Hoong, John Martin Lally, Charles H. Powell |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Lens materials
Chromatography Contact Lenses Hydrochloride Kinetics General Medicine Absorption (skin) Absorption law.invention Equipment Failure Analysis Lens (optics) Ophthalmology chemistry.chemical_compound Models Chemical chemistry law Computer Simulation Myristamidopropyl dimethylamine Ophthalmic Solutions Hydrophobic and Hydrophilic Interactions Optometry Single cycle |
| Zdroj: | Contact Lens and Anterior Eye. 33:9-18 |
| ISSN: | 1367-0484 |
| DOI: | 10.1016/j.clae.2009.10.006 |
| Popis: | To determine if the silicone-type components of new high Dk lens materials contribute significantly to uptake and/or release of two common antimicrobial agents, myristamidopropyl dimethylamine (Aldox) and poly[hexamethylene biguanide hydrochloride] (PHMB), found in multipurpose solutions.Five commercial contact lenses were cycled in lens cases in a PHMB- and an Aldox-containing MPS. Single-cycle soaks (6, 16 or 64h) and multi-cycle soaks (6, 16, 142 and 48h) were used to assess kinetics and saturation effects of uptake. Lens capacity for uptake of each entity was determined using a semi-saturation model. Release kinetics was assessed for these semi-saturated lenses (100-mL MPS-soaked) in 2mL of a tear mimic fluid.Lenses that exhibited low uptake in a single cycle (with 3mL of MPS) became saturated within approximately 3 cycles. PHMB uptake was highest with non-silicone hydrogel (non-SiHy) and/or ionic lenses (approximately 70% depletion in 16h). PHMB uptake by non-ionic SiHy lenses was low (40% depletion in a single 3-mL soak of 64h). Aldox uptake was highest for all SiHy lenses (approximately 80% depletion in 16h).PHMB uptake capacity was highest by ionic and non-SiHy lenses, while Aldox uptake capacity was much higher with all SiHy lenses than with any non-SiHy lens. The slower desorption of PHMB (t(1/2)= approximately 120min) compared to Aldox (t(1/2)= approximately 20min) may partially explain observed higher staining after 2-4h with PHMB products used with some lenses, whereas any clinical effects from Aldox would be expected to manifest soon after insertion. |
| Databáze: | OpenAIRE |
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