Reduced cortical choline acetyltransferase activity in Gerstmann-Sträussler syndrome
| Autor: | S. Gauthier, Samarthji Lal, Paul L. Wood, N.P. Vasavan Nair, Yvon Robitaille, Pierre Etienne, Morrison H. Finlayson |
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| Rok vydání: | 1982 |
| Předmět: |
Pharmacology
Adult Cerebral Cortex Neurons medicine.medical_specialty Gerstmann Syndrome Homovanillic acid Choline acetyltransferase Choline O-Acetyltransferase chemistry.chemical_compound medicine.anatomical_structure Neurochemical Endocrinology Somatostatin Monoamine neurotransmitter chemistry Cortex (anatomy) Internal medicine Muscarinic acetylcholine receptor Nerve Degeneration medicine Cholinergic Humans Female Biological Psychiatry |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 6(4-6) |
| ISSN: | 0278-5846 |
| Popis: | 1. Neurochemical analyses of the medial frontal cortex in a case of Gerstmann-Straussler syndrome revealed a 52% decrease in choline acetyltransferase. 2. In contrast muscarinic receptors, amino acids, monoamines and somatostatin were unchanged. 3. The monoamine metabolites homovanillic acid and 5-hydroxyindole acetic acid were elevated. 4. These data suggest a selective degeneration of cortical cholinergic pathways, as has been observed in Alzheimer's disease. 5. The cholinergic input to the cortex may well therefore play a role in the cognitive deficit of these 2 forms of dementia. |
| Databáze: | OpenAIRE |
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