Preparation of poly(lactic acid)/sintered hydroxyapatite composite biomaterial by supercritical CO2
| Autor: | Lan Gao, Kaibo Chu, Jianru Wang, Xiaojun Niu, Bo Han, Jue Wang, Yumin Zhang, Yanmiao Ma, Xiaoyan Zhai, Liwang Yang, Jianchun Liu |
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| Rok vydání: | 2017 |
| Předmět: |
Absorption of water
Materials science Cell Survival Polyesters 0206 medical engineering Biomedical Engineering Young's modulus 02 engineering and technology Bone and Bones Cell Line Biomaterials chemistry.chemical_compound symbols.namesake Mice Polylactic acid Elastic Modulus Materials Testing Animals Porosity Elastic modulus Osteoblasts Tissue Scaffolds Biomaterial Water General Medicine Carbon Dioxide Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 020601 biomedical engineering Supercritical fluid Compressive strength Durapatite chemistry Chemical engineering Bone Substitutes symbols Cattle 0210 nano-technology |
| Zdroj: | Bio-medical materials and engineering. 29(1) |
| ISSN: | 1878-3619 |
| Popis: | Based on a kind of sintered hydroxyapatite (HA) with a good cytocompatibility, a series of polylactic acid (PLA) and PLA/HA with the various PLA:HA weight ratio (5:5, 4:6, 3:7, 2:8, 1:9) were fabricated by supercritical CO2. The physical and chemical properties were evaluated by pH, degradation, water absorption, porosity, density, mechanical property, and cytotoxicity respectively. With the increase of HA content, the pH value and porosity increased gradually, while weight loss rate and the density showed a gradual downward trend. Existence of HA can drastically improve the hydroscopicity of PLA scaffolds. The compression strength values slightly increased (p>0.05) from 39.96 MPa of PLA to 45.00 MPa of PLA/HA with the ratio of 7:3, subsequently, the values decreased (p |
| Databáze: | OpenAIRE |
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