Sex Differences in the Clinical Features and Outcomes of Patients with Acute Coronary Syndrome Treated with Two Generations (Absorb and Magmaris) of Bioresorbable Vascular Scaffolds
| Autor: | Mateusz Barycki, Maciej Lesiak, Adrian Wlodarczak, Marek Szudrowicz, Jan Jakub Kulczycki, Adrian Doroszko, Magdalena Łanocha, Alicja Gosiewska, Piotr Rola, Karol Turkiewicz |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
sex differences
medicine.medical_specialty Acute coronary syndrome Percutaneous Absorb Article acute coronary syndrome (ACS) Restenosis coronary artery disease (CAD) Internal medicine medicine bioresorbable scaffold (BRS) Myocardial infarction Female population business.industry Magmaris General Medicine medicine.disease Thrombosis First generation gender-related prognosis Conventional PCI Cardiology Medicine percutaneous coronary intervention (PCI) business |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 3768, p 3768 (2021) Journal of Clinical Medicine Volume 10 Issue 17 |
| ISSN: | 2077-0383 |
| Popis: | Background: Despite the developments in percutaneous coronary interventions (PCI), women are still more likely than men to have unfavorable outcomes after PCI performed in Acute Coronary Syndrome (ACS). The mechanisms of this phenomena are not fully understood. Potential benefits of bioresorbable scaffolds (BRS) may be particularly expressed in the female population. Nevertheless, the data available currently are inconsistent and limited. This study evaluated the gender-related differences in the short-term clinical outcomes in ACS patients treated with implantation of two generations of BRS (first generation, Absorb second generation, Magmaris). Methods: The study was divided into two arms. To the first one, we qualified 160 patients with ACS treated with PCI who received 210 Absorb scaffolds. The second arm was composed of 193 patients with ACS who underwent PCI with Magmaris implantation. Results: There were no significant sex-related differences in primary endpoints (cardiovascular-death, myocardial infarction, in-stent thrombosis) or principal secondary endpoints (of target-lesion failure, scaffold restenosis, death from any reason, other cardiovascular events) in either generation of BRS in a 1-year follow-up. Conclusions: Both genders tended to have a similar outcome in routine clinical practice following BRS implantation due to ACS. The magnesium bioresorbable scaffold (Magmaris) early outcome seemed to be more favorable in comparison to the Absorb scaffold. |
| Databáze: | OpenAIRE |
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