Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency
| Autor: | Nima Rezaei, Maryam Fatholahi, Gholamreza Azizi, Reza Yazdani, Asghar Aghamohammadi, Kabir Magaji Hamid, Hassan Abolhassani, Mazdak Ganjalikhani-Hakemi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Common variable immunodeficiency Immunology B-Lymphocyte Subsets IgA Deficiency Apoptosis Lymphocyte proliferation Clinical manifestation Selective IgA deficiency Biology medicine.disease Immunoglobulin A deficiency Pathogenesis 03 medical and health sciences Common Variable Immunodeficiency 030104 developmental biology 0302 clinical medicine T-Lymphocyte Subsets medicine Humans Cytokine secretion Molecular Biology 030215 immunology |
| Zdroj: | Molecular Immunology. 71:1-9 |
| ISSN: | 0161-5890 |
| Popis: | Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibody production, decreased lymphocyte proliferation and defective cytokine secretion. For the first time, we reviewed the role of apoptosis in CVID and SIgAD. |
| Databáze: | OpenAIRE |
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