Retinoic acid signaling regulates proliferation and lamina formation in the developing chick optic tectum
| Autor: | Baba Yogesh, Niveda Udaykumar, Shweta Kukreja, Jonaki Sen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Superior Colliculi
Lamina animal structures Topographic map (neuroanatomy) Retinoic acid Tretinoin Chick Embryo Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Movement Animals Molecular Biology Cell Proliferation 030304 developmental biology 0303 health sciences Cell growth Cell Differentiation Cell Biology Optic tectum Cell biology chemistry sense organs Tectum Chickens 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Developmental Biology. 467:95-107 |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/j.ydbio.2020.09.003 |
| Popis: | The retinotectal system has been extensively studied for investigating the mechanism(s) for topographic map formation. The optic tectum, which is composed of multiple laminae, is the major retino recipient structure in the developing avian brain. Laminar development of the tectum results from cell proliferation, differentiation and migration, coordinated in strict temporal and spatial patterns. However, the molecular mechanisms that orchestrate these complex developmental events, have not been fully elucidated. In this study, we have identified the presence of differential retinoic acid (RA) signaling along the rostro-caudal and dorsoventral axis of the tectum. We show for the first time that loss of RA signaling in the anterior optic tectum, leads to an increase in cell proliferation and gross changes in the morphology manifested as defects in lamination. Detailed analysis points to delayed migration of cells as the plausible cause for the defects in lamina formation. Thus, we conclude that in the optic tectum, RA signaling is involved in maintaining cell proliferation and in regulating the formation of the tectal laminae. |
| Databáze: | OpenAIRE |
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