ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome
| Autor: | Fulvio Guccione, Giuseppe Santangelo, Cristina Gallo, Vincenzo Raieli, Renata Pitino, Cristina Galati, Antonio Marino, Maria Laura Manzo |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Neurology Evans syndrome Dermatology Brief Communication Asymptomatic 03 medical and health sciences Epilepsy 0302 clinical medicine Autoimmune disease medicine Humans 030212 general & internal medicine Child Neuroradiology ADEM SARS-CoV-2 business.industry Fisher-Evans Syndrome Encephalomyelitis Acute Disseminated Headache COVID-19 General Medicine medicine.disease Thrombocytopenia Thalidomide Psychiatry and Mental health Acute disseminated encephalomyelitis RNA Viral Anemia Hemolytic Autoimmune Neurology (clinical) Neurosurgery medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurological Sciences |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | Introduction Sars-CoV-2 is a single-strained RNA virus belonging to Coronaviridae’s family. In pediatric age, the majority of patients is asymptomatic; however, several neurological manifestations associated with Sars-CoV-2 infection have been detected in a percentage of cases ranging from 17.3 to 36.4%. Acute disseminated encephalomyelitis (ADEM) has been recently included among the potential complications of Sars-Cov2 infection. The available data regarding pediatric patient show only one case. Case report We present a case regarding a 6-year-old patient suffering from Fisher-Evans syndrome who was given sirolimus and thalidomide therapy. After 10 days since the first positive nasopharyngeal swab for Sars-CoV-2, in which he had no symptoms, he presented an episode of generalized tonic-clonic seizure with spontaneous resolution. The patient underwent MRI which showed the typical picture of acute disseminated encephalomyelitis. His clinical course was favorable, with a good response to cortisone therapy and a progressive improvement of the neuroradiological and electroencephalographic picture. Conclusions According to our knowledge, this is the second case of an acute disseminated encephalomyelitis following SARS-CoV-2 infection in a pediatric patient, characterized by monosymptomatic onset, in which the immunosuppressive therapy practiced for the Fisher-Evans syndrome has probably contributed to a favorable evolution of ADEM, in contrast to other case described in the literature. |
| Databáze: | OpenAIRE |
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