Acute graft pyelonephritis: a potential cause of acute rejection in renal transplant

Autor: Mounia Amor, Dominique Desvaux, Agathe Pardon, Christophe Baron, Myriam Pastural, Philippe Lang, Vincent Audard, Djamel Dahmane, Philippe Grimbert, Remy Philippe
Rok vydání: 2005
Předmět:
Zdroj: Transplantation. 80(8)
ISSN: 0041-1337
Popis: Acute graft pyelonephritis is a common complication in renal transplant recipients. The consequences of this complication on kidney allograft survival remain controversial. Bacterial infection is likely to activate the immune system, potentially leading to acute or chronic rejection. Here, we report for the first time two documented cases of acute rejection occurring shortly after acute graft pyelonephritis, suggesting that pyelonephritis can initiate acute rejection. The immunologic process leading to the alloimmune response is discussed. These reports suggest that acute rejection should be questioned in case of atypical graft outcome in the context of acute graft pyelonephritis.
Databáze: OpenAIRE