Efficacy of glaucoma drainage devices in uveitic glaucoma and a meta-analysis of the literature
| Autor: | Roger C. W. Wolfs, Jan Pals, Wishal D. Ramdas, Aniki Rothova |
|---|---|
| Přispěvatelé: | Ophthalmology |
| Rok vydání: | 2019 |
| Předmět: |
Intraocular pressure
medicine.medical_specialty genetic structures Glaucoma Baerveldt Weighted mean difference Ahmed Uveitis 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Ophthalmology Uveitic glaucoma medicine Humans In patient Glaucoma Drainage Implants Macular edema business.industry medicine.disease Sensory Systems eye diseases Glaucoma drainage device Meta-analysis 030221 ophthalmology & optometry sense organs business 030217 neurology & neurosurgery |
| Zdroj: | Graefes Archive for Clinical and Experimental Ophthalmology, 257(1), 143-151. Springer-Verlag Graefe's Archive for Clinical and Experimental Ophthalmology |
| ISSN: | 0721-832X |
| Popis: | Purpose To assess the efficacy of glaucoma drainage devices (GDD) in uveitic glaucoma and non-uveitic glaucoma, and to perform a meta-analysis of previously published results to compare with our data. Methods Retrospective case-control study, in which all eyes that underwent GDD surgery were included from 2015 onwards. Cases were defined as patients with uveitic glaucoma. Patients with non-uveitic glaucoma served as controls. To compare our results, a review of the literature was performed using PubMed database. Results A total of 99 eyes were included (38 with uveitic glaucoma). The preoperative IOP was 25.9 ± 7.7 mmHg and 27.9 ± 9.6 mmHg for patients with and without uveitis (p = 0.277). No significant differences were found between patients with and without uveitis in the final IOP or reduction in IOP (44.9% vs. 42.8%, respectively). Within the first year after surgery, 13.2% of cases developed macular edema (vs. 6.6%; p = 0.267) and 15.8% a transient hypotony (vs. 8.2%; p = 0.242). A meta-analysis of 24 studies showed a postoperative weighted mean difference of − 17.8 mmHg and 2.2 lower number of IOP-lowering medications in uveitic glaucoma (compared to − 13.2 mmHg and 3.5 in the current study, respectively). Conclusion GDD surgery in patients with uveitis has a similar effect on IOP as in patients without uveitis. The risks of developing macular edema and hypotony were slightly higher in patients with uveitis, but the results were not statistically significant. These findings are in line with previous reports, though data on the efficacy of GDD surgery and macular edema in uveitic glaucoma is scarce. Electronic supplementary material The online version of this article (10.1007/s00417-018-4156-9) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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