Selenium effects on the carcinogenicity and metabolism of 2-acetylaminofluorene
| Autor: | A.C. Griffin, M.S. Arnott, M.V. Marshall, M.M. Jacobs |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Liver tumor chemistry.chemical_element In Vitro Techniques Hydroxylation Selenium chemistry.chemical_compound Liver Neoplasms Experimental Detoxification Internal medicine polycyclic compounds medicine Animals Biotransformation Carcinogen Hydroxyacetylaminofluorene Metabolism 2-Acetylaminofluorene medicine.disease Rats Endocrinology Liver Oncology chemistry Biochemistry Microsomes Liver Microsome Methylcholanthrene |
| Zdroj: | Cancer Letters. 7:331-338 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(79)80062-2 |
| Popis: | Summary Addition of 4 ppm Se to the drinking water of male albino rats fed diets containing 0.03% 2-acetylaminofluorene (AAF) provided protection against hepatic damage and also resulted in at least 50% reduction in liver tumor incidence. An in vitro assay system utilizing microsomes from Se supplemented or non-supplemented 3-methylcholanthrene (MC) induced rats was used to determine the effect of oral Se intake on the metabolism of AAF. Oral Se administration led to an increase in ring hydroxylation and a decrease in N-hydroxylation. Addition of Se to the microsomal assay system increased 3-OH AAF formation and decreased N-OH AAF formation, thus shifting the balance of metabolism toward detoxification pathways. |
| Databáze: | OpenAIRE |
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