Intravascular ultrasound assessment of novel antiatherosclerotic therapies: rationale and design of the Acyl-CoA:Cholesterol Acyltransferase Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Study
| Autor: | Tammy Churchill, Stephen J. Nicholls, Marlene Goormastic, Steven E. Nissen, E. Murat Tuzcu, Paul Schoenhagen, Tim Crowe, Ilke Sipahi, Kathy Wolski, Lisa Wisniewski |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Coronary Disease Coronary Artery Disease Coronary artery disease Double-Blind Method Internal medicine Intravascular ultrasound Medicine Humans Coronary atherosclerosis Ultrasonography Interventional Randomized Controlled Trials as Topic medicine.diagnostic_test Esterification Indoleacetic Acids business.industry Vascular disease medicine.disease Coronary Vessels medicine.anatomical_structure Atheroma Cholesterol Research Design Circulatory system Angiography Cardiology Disease Progression Female Cardiology and Cardiovascular Medicine business Artery Foam Cells Sterol O-Acyltransferase |
| Zdroj: | American heart journal. 152(1) |
| ISSN: | 1097-6744 |
| Popis: | Background Inhibiting the enzyme acyl-CoA:cholesterol acyltransferase (ACAT) has beneficial effects on foam cell formation and therefore has the potential to favorably influence the progression of coronary atherosclerosis. The aim of this study is to determine whether ACAT inhibition, when added to usual medical care, reduces atheroma progression in subjects with coronary artery disease. Methods Five hundred thirty-four subjects with established coronary artery disease on angiography were randomized to receive the experimental ACAT inhibitor, pactimibe, 100 mg daily or matching placebo for 18 months. The primary efficacy parameter will be the nominal change in percent atheroma volume determined by analysis of pullback intravascular ultrasound (IVUS) images of matched coronary artery segments acquired at baseline and 18-month follow-up. In addition, the effect of pactimibe on plasma lipids and inflammatory markers and the incidence of clinical cardiovascular events will also be assessed. Conclusion Serial IVUS has emerged as a sensitive imaging modality to assess the impact that novel antiatherosclerotic strategies have on the arterial wall. In this study, IVUS will be used to assess whether ACAT inhibition modifies progression of atherosclerotic plaque. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect