Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome

Autor: Naotake Yanagisawa, Takeshi Kurata, Manabu Ogita, Katsumi Miyauchi, Hiroyuki Daida, Ryunosuke Ohkawa, Shinya Okazaki, Yutaka Yatomi, Takayuki Yokoyama, Ken Yokoyama, Tomotaka Dohi, Shuta Tsuboi, Kazuhiro Nakamura
Rok vydání: 2011
Předmět:
Male
medicine.medical_specialty
Acute coronary syndrome
Time Factors
medicine.medical_treatment
Down-Regulation
Coronary Artery Disease
Phospholipase A2
Japan
Angioplasty
Internal medicine
Intravascular ultrasound
Humans
Medicine
Longitudinal Studies
Prospective Studies
Acute Coronary Syndrome
Angioplasty
Balloon
Coronary
Prospective cohort study
Ultrasonography
Interventional
Aged
medicine.diagnostic_test
biology
business.industry
Lipoprotein-associated phospholipase A2
Percutaneous coronary intervention
Middle Aged
medicine.disease
Plaque
Atherosclerotic
Phospholipases A2
Treatment Outcome
1-Alkyl-2-acetylglycerophosphocholine Esterase
Multivariate Analysis
Conventional PCI
biology.protein
Cardiology
Regression Analysis
Female
lipids (amino acids
peptides
and proteins)
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
Biomarkers
Zdroj: Atherosclerosis. 219:907-912
ISSN: 0021-9150
Popis: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a vascular-specific inflammatory enzyme, of which increases are associated with cardiovascular events. However, the relationship between circulating Lp-PLA2 levels and coronary plaque volume has not been clarified in patients with acute coronary syndrome (ACS).We studied 40 patients with ACS (age, 61.4 ± 8.0 years; male, 87.5%; statin use, 45.0%) who had undergone successful percutaneous coronary intervention (PCI). Plaque volume (PV) in non-culprit sites of PCI lesions was precisely determined using grayscale intravascular ultrasound (IVUS) at onset and at six months later. We then analyzed associations among PV, lipid profiles and Lp-PLA2 levels.Circulating Lp-PLA2 levels and PV significantly decreased between baseline and six months of follow-up (458.6 ± 166.7 IU/L vs. 378.4 ± 158.5 IU/L, p0.001 and 82.2 ± 34.8mm(3) vs. 77.3 ± 33.1mm(3), p0.001, respectively). The % change in PV positively and significantly correlated with % change in LDL-C and in the LDL-C/HDL-C ratio (r = 0.444, p = 0.004 and r = 0.462, p = 0.003, respectively). Furthermore, % changes in Lp-PLA2 and in PV correlated even more closely (r = 0.496, p = 0.001). The absolute change in PV also significantly correlated with the change in Lp-PLA2 levels (r = 0.404, p = 0.009).Circulating Lp-PLA2 levels are associated with changes in coronary plaque determined by IVUS in patients with ACS.
Databáze: OpenAIRE
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