Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome
Autor: | Naotake Yanagisawa, Takeshi Kurata, Manabu Ogita, Katsumi Miyauchi, Hiroyuki Daida, Ryunosuke Ohkawa, Shinya Okazaki, Yutaka Yatomi, Takayuki Yokoyama, Ken Yokoyama, Tomotaka Dohi, Shuta Tsuboi, Kazuhiro Nakamura |
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Rok vydání: | 2011 |
Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Time Factors medicine.medical_treatment Down-Regulation Coronary Artery Disease Phospholipase A2 Japan Angioplasty Internal medicine Intravascular ultrasound Humans Medicine Longitudinal Studies Prospective Studies Acute Coronary Syndrome Angioplasty Balloon Coronary Prospective cohort study Ultrasonography Interventional Aged medicine.diagnostic_test biology business.industry Lipoprotein-associated phospholipase A2 Percutaneous coronary intervention Middle Aged medicine.disease Plaque Atherosclerotic Phospholipases A2 Treatment Outcome 1-Alkyl-2-acetylglycerophosphocholine Esterase Multivariate Analysis Conventional PCI biology.protein Cardiology Regression Analysis Female lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business Biomarkers |
Zdroj: | Atherosclerosis. 219:907-912 |
ISSN: | 0021-9150 |
Popis: | Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a vascular-specific inflammatory enzyme, of which increases are associated with cardiovascular events. However, the relationship between circulating Lp-PLA2 levels and coronary plaque volume has not been clarified in patients with acute coronary syndrome (ACS).We studied 40 patients with ACS (age, 61.4 ± 8.0 years; male, 87.5%; statin use, 45.0%) who had undergone successful percutaneous coronary intervention (PCI). Plaque volume (PV) in non-culprit sites of PCI lesions was precisely determined using grayscale intravascular ultrasound (IVUS) at onset and at six months later. We then analyzed associations among PV, lipid profiles and Lp-PLA2 levels.Circulating Lp-PLA2 levels and PV significantly decreased between baseline and six months of follow-up (458.6 ± 166.7 IU/L vs. 378.4 ± 158.5 IU/L, p0.001 and 82.2 ± 34.8mm(3) vs. 77.3 ± 33.1mm(3), p0.001, respectively). The % change in PV positively and significantly correlated with % change in LDL-C and in the LDL-C/HDL-C ratio (r = 0.444, p = 0.004 and r = 0.462, p = 0.003, respectively). Furthermore, % changes in Lp-PLA2 and in PV correlated even more closely (r = 0.496, p = 0.001). The absolute change in PV also significantly correlated with the change in Lp-PLA2 levels (r = 0.404, p = 0.009).Circulating Lp-PLA2 levels are associated with changes in coronary plaque determined by IVUS in patients with ACS. |
Databáze: | OpenAIRE |
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