Children with type-1 diabetes and their unaffected siblings have few er symptoms of asthma
| Autor: | Hilary A Gillmor, Nicola J Leech, I. F. Douek, Polly J. Bingley, Edwin A M Gale |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pediatrics
medicine.medical_specialty Adolescent Population Th2 Cells Wheeze medicine Humans Sibling Child Prospective cohort study education Asthma Type 1 diabetes education.field_of_study business.industry General Medicine Odds ratio Th1 Cells medicine.disease Diabetes Mellitus Type 1 Phenotype England Cohort medicine.symptom business |
| Zdroj: | The Lancet. 353:1850 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(99)00988-5 |
| Popis: | We wanted to establish whether the reduced risk of asthma in children with diabetes had a genetic basis or was in some way related to the diabetic phenotype. Control data for the frequency of symptoms associated with asthma and other atopic conditions are available from a large published survey of children aged 12-14 years, including 2324 children from the Oxford and East Anglia region. 3 is a population-based prospective study that has recruited 1627 families in the former Oxford Regional Health Authority area (population 2·6 million) since 1985. Our database identified 206 probands and 209 unaffected siblings aged 12-14 years within this cohort. Of these, 181 probands and 184 siblings agreed to take part, and 157 and 173, respectively, returned completed questionnaires. Data were therefore available for 76% of the eligible probands and 83% of the siblings. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire of symptoms of asthma and allergy 4 was used in all groups. Only 27% of probands had ever experienced wheeze compared with 42% of the siblings and 51% of controls ( 2 for trend 34, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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