Central and peripheral haemodynamic effects of l-NAME infusion in healthy volunteers
| Autor: | Gary E. McVeigh, Bernard Silke, Lana J. Dixon, C G Hanratty, Douglas R. Morgan, Patrick Allen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Cardiac output Hemodynamics Nitric Oxide Nitric oxide chemistry.chemical_compound Heart rate Humans Medicine Pharmacology (medical) Infusions Intravenous Ultrasonography Pharmacology Dose-Response Relationship Drug biology business.industry General Medicine Peripheral Nitric oxide synthase Forearm NG-Nitroarginine Methyl Ester Blood pressure chemistry Regional Blood Flow Anesthesia biology.protein Nitric Oxide Synthase business Perfusion |
| Zdroj: | European Journal of Clinical Pharmacology. 59:195-199 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/s00228-003-0601-7 |
| Popis: | To evaluate the effects of the intravenous administration of the nitric oxide synthesis inhibitor N(g)nitro-L-arginine methyl ester (L-NAME) in healthy volunteers.L-NAME (0.25, 0.5 and 0.75 mg/kg over 8 min) was infused in 13 healthy male volunteers. Finally, subjects were infused with either L- or D-arginine.L-NAME resulted in dose-dependent falls in heart rate 60 bpm (55-64 bpm) to 49 bpm (46-52 bpm) (P0.01) and increased mean arterial pressure 77.0 mmHg (73.2-80.8 mmHg) to 90.0 mmHg (87.1-92.8 mmHg) (P0.01). The cardiac output was significantly reduced after each L-NAME infusion, and systemic vascular resistance increased linearly over the dosage range. Cardiac stroke volume was significantly reduced only following 0.75 mg/kg/min L-NAME: from 100 ml (91.3-108.7 ml) to 83 ml (74.7-91.4 ml); P0.01. Forearm blood flow was unchanged at any dosage. L-arginine but not D-arginine infusion reversed the haemodynamic effects of L-NAME.Contrasting with the profound dose-dependent effects of L-NAME had significant effects on central haemodynamics but no discernible effects on peripheral blood flow. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink