Gamma Interferon Impedes the Establishment of Herpes Simplex Virus Type 1 Latent Infection but Has No Impact on Its Maintenance or Reactivation in Mice
| Autor: | Julie A. Lekstrom-Himes, Matthew Godleski, Lesley Pesnicak, Sharon E. Straus, Rona A. LeBlanc |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Ultraviolet Rays
viruses medicine.medical_treatment Immunology Eye Infections Viral Herpesvirus 1 Human Biology medicine.disease_cause Polymerase Chain Reaction Microbiology Virus Interferon-gamma Mice Species Specificity Virology Chlorocebus aethiops Virus latency medicine Animals Interferon gamma Vero Cells Mice Knockout Mice Inbred BALB C Virus Activation medicine.disease Virus Latency Mice Inbred C57BL Disease Models Animal Herpes simplex virus Cytokine Real-time polymerase chain reaction Trigeminal Ganglion Insect Science Acute Disease DNA Viral Vero cell Pathogenesis and Immunity medicine.drug |
| Zdroj: | Journal of Virology. 74:6680-6683 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | Murine models of gamma interferon (IFN-γ) deficiency demonstrate the role of this cytokine in attenuating acute herpes simplex virus (HSV) disease; however, the effect of IFN-γ on the establishment and maintenance of neuronal latency and viral reactivation is not known. Using the IFN-γ knockout (GKO) model of IFN-γ deficiency and sensitive quantitative PCR methods, we show that IFN-γ significantly reduces the ganglion content of latent HSV-1 in BALB/c mice, which in turn delays viral time to reactivation following UV irradiation. Similar effects were not seen in the C57BL/6 strain. These results indicate that IFN-γ significantly attenuates latent HSV infection in the mouse model of ocular infection but has no impact on the maintenance of latency or virus reactivation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|