Graphene-Based Scaffolds for Regenerative Medicine
| Autor: | Samuel Pressi, Giorgia Scapin, Enzo Menna, Matteo Gasparotto, Miriam, Pietro Bellet, Anna Fortunato, Francesco Filippini |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Materials science General Chemical Engineering Cellular differentiation Nanotechnology 02 engineering and technology Review tissue regeneration fibers 010402 general chemistry 01 natural sciences Regenerative medicine reduced graphene oxide Nanomaterials law.invention lcsh:Chemistry 2D-scaffolds law General Materials Science Nanotopography stem cell differentiation hydrogels Graphene graphene 021001 nanoscience & nanotechnology 0104 chemical sciences Stem cell fate determination lcsh:QD1-999 graphene graphene oxide reduced graphene oxide tissue regeneration 2D-scaffolds hydrogels fibers stem cell differentiation Self-healing hydrogels graphene oxide 0210 nano-technology |
| Zdroj: | Nanomaterials Nanomaterials, Vol 11, Iss 404, p 404 (2021) |
| ISSN: | 2079-4991 |
| Popis: | Leading-edge regenerative medicine can take advantage of improved knowledge of key roles played, both in stem cell fate determination and in cell growth/differentiation, by mechano-transduction and other physicochemical stimuli from the tissue environment. This prompted advanced nanomaterials research to provide tissue engineers with next-generation scaffolds consisting of smart nanocomposites and/or hydrogels with nanofillers, where balanced combinations of specific matrices and nanomaterials can mediate and finely tune such stimuli and cues. In this review, we focus on graphene-based nanomaterials as, in addition to modulating nanotopography, elastic modulus and viscoelastic features of the scaffold, they can also regulate its conductivity. This feature is crucial to the determination and differentiation of some cell lineages and is of special interest to neural regenerative medicine. Hereafter we depict relevant properties of such nanofillers, illustrate how problems related to their eventual cytotoxicity are solved via enhanced synthesis, purification and derivatization protocols, and finally provide examples of successful applications in regenerative medicine on a number of tissues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|