COVID-19 in adults with dementia: clinical features and risk factors of mortality-a clinical cohort study on 125 patients
| Autor: | Véronique François, Julien Dumurgier, Elsa Mhanna, Claire Hourregue, Dalenda Cherni Gherissi, Diane Nankam, Fernanda Albuquerque, Lisette Volpe-Gillot, Julien Azuar, Iana Pissareva, Clément Aveneau, Claire Paquet, Raphaelle Razou Feroldi, Lina Grosset, Barbara Maakaroun, Manon Lebozec, Agathe Vrillon |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Neurology Cognitive Neuroscience Comorbidity Prognostic factors lcsh:RC346-429 lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine COVID-19 Testing Risk Factors Internal medicine Case fatality rate medicine Dementia Humans 030212 general & internal medicine Prospective Studies Mortality Prospective cohort study Vascular dementia lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry lcsh:Neurology. Diseases of the nervous system Aged 80 and over business.industry SARS-CoV-2 Research COVID-19 medicine.disease Delirium Female Neurology (clinical) France medicine.symptom business 030217 neurology & neurosurgery Kidney disease |
| Zdroj: | Alzheimer's Research & Therapy Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-8 (2021) |
| ISSN: | 1758-9193 |
| Popis: | Background There is limited evidence on the characteristics and outcome of patients with dementia hospitalised for novel coronavirus infection (COVID-19). Method We conducted a prospective study in 2 gerontologic COVID units in Paris, France, from March 14, 2020, to May 7, 2020. Patients with dementia hospitalised for confirmed COVID-19 infection were systematically enrolled. A binary logistic regression analysis was performed to identify factors associated with mortality at 21 days. Results We included 125 patients. Median age was 86 (IQI 82–90); 59.4% were female. Most common causes of dementia were Alzheimer’s disease, mixed dementia and vascular dementia. 67.2% had ≥ 2 comorbidities; 40.2% lived in a long-term care facility. The most common symptoms at COVID-19 onset were confusion and delirium (82.4%), asthenia (76.8%) and fever (72.8%) before polypnea (51.2%) and desaturation (50.4%). Falls were frequent at the initial phase of the disease (35.2%). The fatality rate at 21 days was 22.4%. Chronic kidney disease and CRP at admission were independent factors of death. Persisting confusion, mood and behavioural disorders were observed in survivors (19.2%). Conclusion COVID-19 in demented individuals is associated with severe outcome in SARS-CoV-2 infection and is characterised by specific clinical features and complications, with confusion and delirium at the forefront. COVID-19 testing should be considered in front of any significant change from baseline. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |