Antimicrobial resistance in Cambodia: a review
| Autor: | Paul Turner, Thomas A N Reed, Agathe de Lauzanne, Vandarith Nov, Lkhagvadorj Vanchinsuren, Sreng Bun, Sokerya Seng, Nicola Townell, Thong Phe, Kristina Osbjer, Thyl Miliya, Joanne Letchford, Sidonn Krang, Darapheak Chau, Monidarin Chou, Borann Sar, Sovann Ly, Youlet By |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty 030106 microbiology Antimicrobial susceptibility Context (language use) lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Ampicillin Internal medicine Drug Resistance Bacterial medicine Escherichia coli Humans lcsh:RC109-216 030212 general & internal medicine Bacteria business.industry 3rd generation cephalosporins General Medicine Anti-Bacterial Agents Infectious Diseases Systematic review Gentamicin business Cambodia medicine.drug |
| Zdroj: | International Journal of Infectious Diseases, Vol 85, Iss, Pp 98-107 (2019) |
| ISSN: | 1878-3511 |
| Popis: | Objectives: Following the launch of the Global Antimicrobial Resistance Surveillance System (GLASS), antimicrobial resistance (AMR) rates in many countries remain poorly described. This review provides an overview of published AMR data from Cambodia in the context of recently initiated national human and food-animal surveillance. Methods: PubMed and the Cochrane Database of Systematic Reviews were searched for articles published from 2000 to 2018, which reported antimicrobial susceptibility testing (AST) data for GLASS specific organisms isolated from Cambodia. Articles were screened using strict inclusion/exclusion criteria. AST data was extracted, with medians and ranges of resistance rates calculated for specific bug-drug combinations. Results: Twenty-four papers were included for final analysis, with 20 describing isolates from human populations. Escherichia coli was the most commonly described organism, with median resistance rates from human isolates of 92.8% (n = 6 articles), 46.4% (n = 4), 55.4% (n = 8), and 46.4% (n = 5) to ampicillin, 3rd generation cephalosporins, fluoroquinolones, and gentamicin respectively. Conclusions: Whilst resistance rates are high for several GLASS organisms, there were insufficient data to draw robust conclusions about the AMR situation in Cambodia. The recently implemented national AMR surveillance systems will begin to address this data gap. Keywords: Antimicrobial resistance, Cambodia, Bacteria, Review, One Health |
| Databáze: | OpenAIRE |
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