Lactobacillus iners-dominated vaginal microbiota is associated with increased susceptibility to Chlamydia trachomatis infection in Dutch women: a case–control study
| Autor: | Henry J. C. de Vries, Robin van Houdt, Jacques Ravel, Arjen G. C. L. Speksnijder, Bing Ma, Sylvia M. Bruisten |
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| Přispěvatelé: | Medical Microbiology and Infection Prevention, AII - Infectious diseases, Dermatology |
| Rok vydání: | 2017 |
| Předmět: |
vaginal microbiology
0301 basic medicine 030106 microbiology sexual health Physiology Context (language use) Dermatology Logistic regression molecular epidemiology Article 03 medical and health sciences Lactobacillus Lactobacillus iners medicine Prospective cohort study Molecular epidemiology biology business.industry Case-control study chlamydia infection biology.organism_classification medicine.disease 030104 developmental biology Infectious Diseases Immunology women business Dysbiosis |
| Zdroj: | Sexually Transmitted Infections, 94(2), 117-123. BMJ Publishing Group van Houdt, R, Ma, B, Bruisten, S M, Speksnijder, A G C L, Ravel, J & de Vries, H J C 2018, ' Lactobacillus iners-dominated vaginal microbiota is associated with increased susceptibility to Chlamydia trachomatis infection in Dutch women: A case-control study ', Sexually Transmitted Infections, vol. 94, no. 2, pp. 117-123 . https://doi.org/10.1136/sextrans-2017-053133 Epidemiology, 1994(2), 117-123. Philadelphia: Lippincott, Williams & Wilkins |
| ISSN: | 1472-3263 1368-4973 |
| DOI: | 10.1136/sextrans-2017-053133 |
| Popis: | IntroductionThis prospective study aimed to study the composition and structure of the vaginal microbiota prior to Chlamydia trachomatis infection.MethodsA nested case–control study was performed in 122 women, half of which acquired C. trachomatis within a year after their first visit. At the first visit, the composition and structure of vaginal microbial communities were analysed using 16S rRNA sequencing in the context of the sociodemographic and sexual risk behaviour information using logistic regression.ResultsFive vaginal community state types (CSTs) were identified. Four CSTs were dominated by Lactobacillus spp., of which L. crispatus (37%) and L. iners (33%) were the most common. One CST was characterised by the absence of Lactobacillus spp. (25%) and the presence of an array of strict and facultative anaerobes. Multivariate logistic regression analysis revealed that women with a L. iners-dominated CST had an increased risk of C. trachomatis infection (p=0.04; OR: 2.6, 95% CI 1.0 to 6.6).ConclusionsThe distribution of CSTs dominated by Lactobacillus spp. agreed with previous studies. However, the frequency of dysbiosis among Caucasian women was relatively high (24%). Having vaginal microbiota dominated by L. iners was associated with an increased risk for C. trachomatis infection. Therefore, we hypothesise that specific signatures of vaginal microbiota are indicative of increased host predisposition to acquiring STIs. |
| Databáze: | OpenAIRE |
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