Cannabinoid Modulation of Frontolimbic Activation and Connectivity During Volitional Regulation of Negative Affect
| Autor: | Christine A. Rabinak, Shoko Mori, Stephanie M. Gorka, Maryssa Lyons, K. Luan Phan, Mike Angstadt |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Prefrontal Cortex Neuropsychological Tests Brain mapping Arousal Cognitive reappraisal 03 medical and health sciences Young Adult 0302 clinical medicine Cognition Double-Blind Method mental disorders Neural Pathways medicine Image Processing Computer-Assisted Humans Dronabinol Prefrontal cortex Pharmacology Cannabinoid Receptor Agonists Brain Mapping medicine.diagnostic_test organic chemicals Psychophysiological Interaction Amygdala Healthy Volunteers 030227 psychiatry Dorsolateral prefrontal cortex Oxygen Psychiatry and Mental health Affect medicine.anatomical_structure Female Original Article Psychology Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41(7) |
| ISSN: | 1740-634X |
| Popis: | Behavioral and brain research indicates that administration of Δ(9)-tetrahydrocannabinol (THC) alters threat perception and enhances the suppression of conditioned fear responses via modulation of the frontolimbic circuit. No prior studies, however, have examined whether THC also affects volitional forms of emotion processing such as cognitive reappraisal. The aim of the current study was therefore to examine the effects of THC on frontolimbic activation and functional connectivity during cognitive reappraisal in a sample of healthy adults. The study was a randomized, double-blind, placebo-controlled, between-subject design and all participants ingested either an oral dose of synthetic THC (n=41) or placebo (n=37) before completion of an emotion regulation task during functional magnetic resonance imaging (fMRI). Functional connectivity was assessed using generalized psychophysiological interaction (gPPI) analyses. Results indicated that although there were no group differences in self-reported attenuation of negative affect during cognitive reappraisal, relative to placebo, THC increased amygdala activation and reduced amygdala and dorsolateral prefrontal cortex (dlPFC) functional coupling during cognitive reappraisal of emotionally negative pictures. This suggests that in addition to automatic emotional processes, THC affects frontolimbic functioning during cognitive reappraisal. |
| Databáze: | OpenAIRE |
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