Increased incidence of hepatitis B markers in children with sickle-cell anemia
| Autor: | K. H. Flach, T. Buck, P. O. Abiodun, O. J. Fatunde |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
HBsAg
medicine.medical_specialty Anemia Anemia Sickle Cell medicine.disease_cause Gastroenterology Risk Factors Internal medicine medicine Humans Child Hepatitis B virus Hepatitis B Surface Antigens biology business.industry Incidence (epidemiology) Age Factors virus diseases Infant Hematology General Medicine Hepatitis B medicine.disease biology.organism_classification digestive system diseases Sickle cell anemia Hemoglobinopathy Hepadnaviridae Child Preschool Immunology Carrier State business |
| Zdroj: | Blut. 58(3) |
| ISSN: | 0006-5242 |
| Popis: | Screening of 143 children 6 months to 12 years of age with sickle-cell anemia showed that 39.2% were HBsAg-positive as compared with 19.3% of the 161 control children of the same age group, who had Hb genotype AA (chi 2 = 14.7383; P less than 0.001). Fifty percent of the HbSS children under the age of 1 year were HBsAg-positive as opposed to 4.3% of the control group (chi 2 = 9.1955; P less than 0.001), while 28.6% of patients were HBsAg-positive at the age of 4 years compared with only 7.4% of the controls at the same age. The incidence of anti-HBc in both groups was similar. Markers of HBV infection (HBsAg + anti-HBc) were, however, on the whole higher in the patients with sickle-cell anemia [88/118 (74.6%)] than in the controls [54/88 (61.3%; P less than 0.005)]. |
| Databáze: | OpenAIRE |
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