Current Advances in Hypertrophic Scar and Keloid Management
| Autor: | Sabrina Cugno, Natasha Barone, Amanda M. Murphy, Peter G. Davison, Joshua Vorstenbosch, Tyler Safran |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.disease Dermatology Review article Psychological health 030207 dermatology & venereal diseases 03 medical and health sciences Hypertrophic scar 0302 clinical medicine Keloid Fibrosis 030220 oncology & carcinogenesis Etiology Medicine Surgery Hypertrophic scars skin and connective tissue diseases business Wound healing |
| Zdroj: | Semin Plast Surg |
| ISSN: | 1536-0067 1535-2188 |
| DOI: | 10.1055/s-0041-1731461 |
| Popis: | Hypertrophic scars and keloids are caused by excessive tissue response to dermal injury due to local fibroblast proliferation and collagen overproduction. This response occurs because of pathologic wound healing due to dysregulation in the inflammatory, proliferative, and/or remodeling phase. Patients with hypertrophic scars or keloids report reduced quality of life, physical status, and psychological health. Hypertrophic scars or keloids will develop in 30 to 90% of individuals, and despite their prevalence, treatment remains a challenge. Of the treatments currently available for hypertrophic scars and keloids few have been adequately supported by studies with appropriate experimental design. Here, we aim to review the available literature to provide up-to-date information on the etiology, epidemiology, histology, pathophysiology, prevention, and management options available for the treatment of hypertrophic scars and keloids and highlight areas where further research is required. |
| Databáze: | OpenAIRE |
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