Maternal Exposure to Low Levels of Corticosterone during Lactation Protects against Experimental Inflammatory Colitis-Induced Damage in Adult Rat Offspring
| Autor: | Simona Agostini, Giovanna Improta, Vassilia Theodorou, Carla Petrella, Manuela Zinni, Valerie Bacquie, Paola Casolini, Maria Broccardo, Chiara Giuli |
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| Přispěvatelé: | Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Neuro-Gastroentérologie & Nutrition (ToxAlim-NGN) |
| Rok vydání: | 2014 |
| Předmět: |
Male
Corticotropin-Releasing Hormone receptor [SDV]Life Sciences [q-bio] lcsh:Medicine corticotropin-releasing-factor colonic barrier dysfunction stress-related alterations environmental enrichment childhood abuse motor function glucocorticoids intestine disease Neonatal Care Inflammatory bowel disease Eating chemistry.chemical_compound 0302 clinical medicine Corticosterone Lactation Medicine and Health Sciences lcsh:Science Immune Response 0303 health sciences Multidisciplinary Colitis Immunohistochemistry 3. Good health medicine.anatomical_structure Female medicine.symptom Research Article medicine.medical_specialty Colon Offspring Blotting Western Immunology Inflammation Gastroenterology and Hepatology Protective Agents Research and Analysis Methods Receptors Corticotropin-Releasing Hormone 03 medical and health sciences Chymases Internal medicine medicine Animals Animal Models of Disease Rats Wistar Peroxidase 030304 developmental biology business.industry lcsh:R Body Weight Inflammatory Bowel Disease Biology and Life Sciences medicine.disease Health Care Endocrinology Animals Newborn Trinitrobenzenesulfonic Acid chemistry Animal Studies lcsh:Q Intestinal Disorder business 030217 neurology & neurosurgery Hormone |
| Zdroj: | Plos One 11 (9), . (2014) PLoS ONE PLoS ONE, Public Library of Science, 2014, 9 (11), ⟨10.1371/journal.pone.0113389⟩ PLoS ONE, Vol 9, Iss 11, p e113389 (2014) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0113389⟩ |
| Popis: | International audience; Opposing emotional events (negative/trauma or positive/maternal care) during the postnatal period may differentially influence vulnerability to the effects of stress later in life. The development and course of intestinal disorders such as inflammatory bowel disease are negatively affected by persistent stress, but to date the role of positive life events on these pathologies has been entirely unknown. In the present study, the effect of early life beneficial experiences in the development of intestinal dysfunctions, where inflammation and stress stimuli play a primary role, was investigated. As a "positive'' experimental model we used adult male rat progeny nursed by mothers whose drinking water was supplemented with moderate doses of corticosterone (CORT) (0.2 mg/ml) during the lactation period. Such animals have been generally shown to cope better with different environmental situations during life. The susceptibility to inflammatory experimental colitis induced by intracolonic infusion of TNBS (2,4,6-trinitrobenzenesulphonic acid) was investigated in CORT-nursed rats in comparison with control rats. This mild increase in maternal corticosterone during lactation induced, in CORT-nursed rats, a long lasting protective effect on TNBS-colitis, characterized by improvements in some indices of the disease (increased colonic myeloperoxidase activity, loss of body weight and food intake) and by the involvement of endogenous peripheral pathways known to participate in intestinal disorder development (lower plasma corticosterone levels and colonic mast cell degranulation, alterations in the colonic expression of both corticotrophin releasing factor/CRF and its receptor/CRH-1R). All these findings contribute to suggesting that the reduced vulnerability to TNBS-colitis in CORT-nursed rats is due to recovery from the colonic mucosal barrier dysfunction. Such long lasting changes induced by mild hormonal manipulation during lactation, making the adult also better adapted to colonic inflammatory stress, constitute a useful experimental model to investigate the etiopathogenetic mechanisms and therapeutic treatments of some gastrointestinal diseases. |
| Databáze: | OpenAIRE |
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