Studies on the Synthesis of NG-Nitro-L-Arginine Derivatives and their Effects on Septic Shock
| Autor: | Wang Chao, Peng Shiqi, Zhou Kexiang, Zhao Ming, Yang Junke, Wu Saizhu, Gu Mingdi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
inorganic chemicals
Arginine Chemistry Stereochemistry Septic shock Blood Pressure General Medicine respiratory system medicine.disease Nitroarginine Shock Septic complex mixtures Biochemistry Rats respiratory tract diseases Random Allocation In vivo Nitro medicine Animals Enzyme Inhibitors Rats Wistar Biotechnology |
| Zdroj: | Preparative Biochemistry and Biotechnology. 30:241-246 |
| ISSN: | 1532-2297 1082-6068 |
| Popis: | (HCl·NG - NO2 - Arg)2 Lys - OCH3, (HCl·NG - NO2 - Arg)2Lys- OH, [(HCl·NG - NO2 - Arg)2Lys]2Lys - OCH3, and [(HCl·NG - NO2-Arg)2Lys]2Lys-OH were synthesized by use of a solution method. Their effect on septic shock was studied in vivo. The results indicate that increasing the number of NG-NO2-Arg residues in a molecule may be useful to improve the response to septic shock. |
| Databáze: | OpenAIRE |
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