Lymphadenopathy Associated Virus Infection of a Blood Donor—Recipient Pair with Acquired Immunodeficiency Syndrome
| Autor: | Harold W. Jaffe, Vaniambadi S. Kalyanaraman, M. S. Gottlieb, P Feorino, D. P. Francis, F. A. Murphy, J.C. Chermann, T. T. Spira, C. D. Cabradilla, D. T. Warfield, J. S. Mcdougal, A. K. Harrison, James W. Curran, D. Goldfinger, Françoise Barré-Sinoussi, Luc Montagnier, H. W. Haverkos |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Acquired Immunodeficiency Syndrome Multidisciplinary Lymphadenopathy associated virus Transfusion Reaction Blood Donors Core protein Competitive radioimmunoassay Biology Antibodies Viral medicine.disease biology.organism_classification Deltaretrovirus Virology Retroviridae Blood donor Retrovirus Acquired immunodeficiency syndrome (AIDS) Antigen Immunology medicine Humans Female Retroviridae Infections |
| Zdroj: | Science. 225:69-72 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.6328663 |
| Popis: | A retrovirus isolated from three patients with the acquired immunodeficiency syndrome (AIDS) in the United States was morphologically and antigenically identical to lymphadenopathy associated virus isolated in France. Two of these isolates were from a blood donor-recipient pair, each of whom developed AIDS. Lymphadenopathy associated virus was isolated from the blood donor's lymphocytes 12 months after his onset of AIDS symptoms and from the blood recipient's lymphocytes 1 month after her onset of AIDS symptoms. Two isolates from the blood donor-recipient pair and an isolate from an epidemiologically unrelated homosexual man were examined by competitive radioimmunoassay to determine their antigenic relatedness to each other and to other human retroviruses. The major core proteins (p25) of the isolates were antigenically identical and all three isolates were identical to prototype lymphadenopathy associated virus isolated in France. |
| Databáze: | OpenAIRE |
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