Dopamine-β-Hydroxylase Activity and Homovanillic Acid in Spinal Fluid of Schizophrenics with Brain Atrophy
| Autor: | Ronald O. Rieder, D. E. Sternberg, Philip T. Ninan, Markku Linnoila, W. B. van Kammen, D.P. van Kammen, Mika Scheinin, Lee S. Mann, Marder |
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| Rok vydání: | 1983 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Dopamine Dopamine neurotransmission Dopamine beta-Hydroxylase chemistry.chemical_compound Atrophy Internal medicine medicine Animals Humans Aged Phenylacetates Multidisciplinary Cerebral Spinal Fluid business.industry Homovanillic acid Brain Homovanillic Acid Middle Aged medicine.disease Rats Endocrinology medicine.anatomical_structure chemistry Ventricle Schizophrenia Dopamine beta-hydroxylase activity Tomography X-Ray Computed business Antipsychotic Agents medicine.drug |
| Zdroj: | Science. 220:974-977 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.6133351 |
| Popis: | Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients. |
| Databáze: | OpenAIRE |
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