Management of Hypertension in Patients With Diabetes Using an Amlodipine-, Olmesartan Medoxomil-, and Hydrochlorothiazide-Based Titration Regimen
| Autor: | Richard Sachson, Ali Shojaee, Chunlin Qian, Joel M. Neutel, Thomas Littlejohn, C. Venkata S. Ram, Kathy A. Stoakes |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Diastole Tetrazoles Placebo Hydrochlorothiazide Internal medicine Diabetes mellitus medicine Humans Amlodipine Antihypertensive Agents Aged Aged 80 and over Olmesartan Medoxomil business.industry Imidazoles Middle Aged medicine.disease Drug Combinations Treatment Outcome Blood pressure Diabetes Mellitus Type 2 Hypertension Ambulatory Cardiology Drug Therapy Combination Female Cardiology and Cardiovascular Medicine Olmesartan business Diabetic Angiopathies medicine.drug |
| Zdroj: | The American Journal of Cardiology. 107:1346-1352 |
| ISSN: | 0002-9149 |
| Popis: | The safety and efficacy of an amlodipine/olmesartan medoxomil (OM)-based titration regimen was assessed in patients with type 2 diabetes mellitus and hypertension. After a 2- to 3-week placebo run-in period, 207 patients received amlodipine 5 mg and were uptitrated to amlodipine/OM 5/20, 5/40, and 10/40 mg and then amlodipine/OM 10/40 mg plus hydrochlorothiazide 12.5 and 25 mg in a step-wise manner at 3-week intervals if the seated blood pressure (BP) remained ≥120/70 mm Hg. The primary end point was the change from baseline in the mean 24-hour ambulatory systolic BP after 12 weeks of treatment. The baseline mean ± SD seated cuff systolic/diastolic BP was 158.8 ± 13.1/89.1 ± 10.1 mm Hg and the mean ± SD 24-hour ambulatory systolic/diastolic BP was 144.4 ± 11.7/81.6 ± 9.8 mm Hg. At week 12, the change from baseline in the mean ± SEM 24-hour ambulatory systolic/diastolic BP was -19.9 ± 0.8/-11.2 ± 0.5 mm Hg (p0.0001 vs baseline), and 70% of patients had achieved a 24-hour ambulatory BP target of130/80 mm Hg. At the end of 18 weeks of active treatment in patients uptitrated to amlodipine/OM 10/40 mg plus hydrochlorothiazide 25 mg, the change from baseline in the mean ± SEM seated BP was -28.0 ± 1.5/-13.7 ± 1.0 mm Hg (p0.0001 vs baseline), with 62% of patients reaching the guideline-recommended seated BP goal of130/80 mm Hg. Drug-related treatment-emergent adverse events occurred in 19.3% of patients. The most frequent events were peripheral edema (6%), dizziness (3%), and hypotension (2%). In conclusion, this amlodipine/OM-based titration regimen was well tolerated and effectively lowered BP throughout the 24-hour dosing interval in patients with hypertension and type 2 diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect