A pH-responsive mesoporous silica nanoparticle-based drug delivery system for targeted breast cancer therapy
| Autor: | Jie Chang, Liufang Mo, Jinfeng Song, Xiaochen Wang, Hanhan Liu, Chenchen Meng, Yijun Wu |
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| Rok vydání: | 2022 |
| Předmět: |
Drug Carriers
animal structures technology industry and agriculture Biomedical Engineering Breast Neoplasms macromolecular substances General Chemistry General Medicine Hydrogen-Ion Concentration Silicon Dioxide Drug Delivery Systems Doxorubicin Humans Nanoparticles Female General Materials Science sense organs Nanoparticle Drug Delivery System Porosity |
| Zdroj: | Journal of Materials Chemistry B. 10:3375-3385 |
| ISSN: | 2050-7518 2050-750X |
| Popis: | In order to make the drug specifically aggregate at the tumor site, we had developed a targeted drug delivery system based on pH responsive mesoporous silica nanoparticles. Mesoporous silica nanoparticles (MSN-COOH) were prepared and doxorubicin (DOX) was loaded into the pores of MSN-COOH, and then polyethyleneimine (PEI) and anisamide (AA) were modified on the surface of mesoporous silica, named DOX@MSN-PEI-AA(DMPA). DMPA specifically entered tumor cells through AA-mediated receptor endocytosis; PEI dissociated from the surface of the MSN in the acidic environment of cellular lysosomes/endosomes due to protonation of PEI, resulting in steady release of the encapsulated DOX from the pores of MSN in the cytoplasm of the target cells. |
| Databáze: | OpenAIRE |
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