Severe ascites with hypothyroidism and elevated CA125 concentration: a case report
| Autor: | Naotsuka Okayama, Kazuhiro Yamada, Ryosuke Kimura, T. Mizuno, Takashi Joh, Kenro Imaeda, Kazuko Wakami, Yoshinobu Kamiya |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
endocrine system Pathology medicine.medical_specialty endocrine system diseases Pleural effusion Hormone Replacement Therapy Endocrinology Diabetes and Metabolism Malignancy Pathogenesis Endocrinology Hypothyroidism Ascites medicine Humans business.industry Thyroid Primary hypothyroidism medicine.disease Thyroxine medicine.anatomical_structure CA-125 Antigen Female Myxedema Thyroid function medicine.symptom business Immunoglobulins Thyroid-Stimulating |
| Zdroj: | Endocrine journal. 54(5) |
| ISSN: | 1348-4540 |
| Popis: | Ascites caused by hypothyroidism is rare and the pathogenesis is unclear. Several reports have presented cases of progressive ascites with hypothyroidism and elevated tumor markers. We report a 31-year-old female case with massive ascites and elevated serum CA 125 concentrations. The patient had no typical feature of hypothyroidism except an accumulation of ascitic fluid which showed elevated total protein concentration and a high serum-ascites albumin gradient (SAAG). There was no finding of malignancy. Following thyroid hormone replacement, the ascites was completely resolved accompanied by reduced concentrations of serum CA125. In general, primary hypothyroidism with ascites presents with coexisting massive pericardial or pleural effusion. The massive ascites and increased serum CA125 concentrations may have led us to make the incorrect diagnosis of ovarian malignancy. The evaluation of thyroid function is useful to determine the pathology of high-protein ascites or elevated tumor markers, and ascites may be treatable by thyroid replacement therapy. |
| Databáze: | OpenAIRE |
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