Tumoral Expression of CD166 in Human Esophageal Squamous Cell Carcinoma: Implications for Cancer Progression and Prognosis
| Autor: | Xiaoshan Zhang, Xueru Zhao, Zhenfeng Li, Guanglin Cui, Aping Yuan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Fetal Proteins
Male Cancer Research Esophageal Neoplasms Cell Adhesion Molecules Neuronal Stem cell marker Esophageal squamous cell carcinoma Cancer stem cell Antigens CD medicine Overall survival Humans Radiology Nuclear Medicine and imaging Pharmacology Cluster of differentiation business.industry Cancer General Medicine Middle Aged medicine.disease Prognosis Oncology Cancer research Disease Progression Female Esophageal Squamous Cell Carcinoma business |
| Zdroj: | Cancer biotherapyradiopharmaceuticals. 35(3) |
| ISSN: | 1557-8852 |
| Popis: | Accumulating data showed that cancer stem cells (CSCs) identified by cell surface markers contribute to the initiation, progression, and prognosis of human cancers. In this study, the expression of CSC candidates CD166, CD44, and Lgr5 in 65 cases of esophageal squamous cell carcinoma (ESCC) and 16 cases of control esophageal tissues were examined with immunohistochemistry (IHC). The correlation between tumoral expression levels of these CSC candidates and clinicopathological variables was analyzed. IHC results showed that the expression of CD166 in esophageal control tissues was completely negative, but it was in 87.69% (57/65) ESCC tissues. The expression of CD44 and Lgr5 did not differ between esophageal control tissues and ESCC tissues ( |
| Databáze: | OpenAIRE |
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