Comparison of LC–MS-MS and GC–MS Analysis of Benzodiazepine Compounds Included in the Drug Demand Reduction Urinalysis Program
| Autor: | Erick Roman Perez, James E. Evans, Stedra L. Stillman, Joshua A. Knapp, Carl K. Horn, Darryl P. Arfsten |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Urinalysis
medicine.drug_class Flurazepam Health Toxicology and Mutagenesis Pharmacology Toxicology 01 natural sciences Gas Chromatography-Mass Spectrometry Analytical Chemistry 03 medical and health sciences Benzodiazepines 0302 clinical medicine Limit of Detection Tandem Mass Spectrometry medicine Environmental Chemistry Humans Sample preparation 030216 legal & forensic medicine Benzodiazepine Chemical Health and Safety Chromatography medicine.diagnostic_test Temazepam Chemistry 010401 analytical chemistry Lorazepam Articles 0104 chemical sciences Oxazepam Gas chromatography–mass spectrometry medicine.drug Chromatography Liquid |
| Popis: | Liquid chromatography-tandem mass spectrometry (LC-MS-MS) offers specific advantages over gas chromatography-mass spectrometry (GC-MS) such as the ability to identify and measure a broader range of compounds with minimal sample preparation. Comparative analysis of LC-MS-MS versus GC-MS was performed for urinalysis detection of five benzodiazepine compounds currently part of the Department of Defense (DoD) Drug Demand Reduction Program (DDRP) testing panel; alpha-hydroxyalprazolam, oxazepam, lorazepam, nordiazepam and temazepam. In the analyses of internally prepared control urine samples at concentrations around the DDRP administrative decision point for benzodiazepines (100 ng/mL), both technologies produced comparable results with average accuracies between 99.7 and 107.3% and average coefficients of variation (%CV) |
| Databáze: | OpenAIRE |
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