Vitreous substitutes: An overview of the properties, importance, and development
| Autor: | Manoj Kumar Yadav, Shiv Dutt Purohit, Rohan Chawla, Saugata Hazra, Hemant Singh, Indu Yadav, Thirumurthy Velpandian, Narayan Chandra Mishra, Sakchi Bhushan |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Materials science Eye Diseases genetic structures Ocular surgery medicine.medical_treatment Biomedical Engineering Potential candidate Biocompatible Materials Vitrectomy 02 engineering and technology Biomaterials 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Humans Macular hole Vitreoretinal Surgeries Retinal detachment Hydrogels 021001 nanoscience & nanotechnology medicine.disease eye diseases Vitreous Body medicine.anatomical_structure Lens (anatomy) Vitreous hemorrhage 030221 ophthalmology & optometry sense organs 0210 nano-technology |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials. 109:1156-1176 |
| ISSN: | 1552-4981 1552-4973 |
| Popis: | Vitreous or vitreous humor is a complex transparent gel that fills the space between the lens and retina of an eye and acts as a transparent medium that allows light to pass through it to reach the photoreceptor layer (retina) of the eye. The vitreous humor is removed in ocular surgery (vitrectomy) for pathologies like retinal detachment, macular hole, diabetes-related vitreous hemorrhage detachment, and ocular trauma. Since the vitreous is not actively regenerated or replenished, there is a need for a vitreous substitute to fill the vitreous cavity to provide a temporary or permanent tamponade to the retina following some vitreoretinal surgeries. An ideal vitreous substitute could probably be left inside the eye forever. The vitreous humor is transparent, biocompatible, viscoelastic and highly hydrophilic; polymeric hydrogels with these properties can be a potential candidate to be used as vitreous substitutes. To meet the tremendous demand for the vitreous substitute, many scientists all over the world have developed various kinds of vitreous substitutes or tamponade agent. Vitreous substitutes, whatsoever developed till date, are associated with several advantages and disadvantages, and there is no ideal vitreous substitute available till date. This review highlights the polymer-based vitreous substitutes developed so far, along with their advantages and limitations. The gas-based and oil-based substitutes have also been discussed but very briefly. |
| Databáze: | OpenAIRE |
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