Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso

Autor: Florence Abravanel, Isaïe Medah, Jérémi Rouamba, Jacques Izopet, Amadou Dicko, Souleymane Tassembedo, Brice Bicaba, Thérèse Kagoné, Seydou Yaro, Dramane Kania, Hervé Hien, Judith Mbombi Mantono, Oumar Traoré, Chloé Dimeglio, Bachirou Tinto, Sylvie Zida, Nicolas Meda, Edouard Tuaillon
Přispěvatelé: Institut de Mathématiques de Toulouse UMR5219 (IMT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz, Centre Muraz [Bobo-Dioulasso, Burkina Faso], Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Université Joseph Ki-Zerbo [Ouagadougou] (UJZK), Ministère de la Santé [Burkina Faso], Institut de l'Environnement et Recherches Agricoles [Ouagadougou] (INERA), Institut de Recherche pour le Développement (IRD), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Catholique de l'Afrique de l'Ouest (UCAO), Agence nationale de biosécurité, Etablissement français du don du sang [Montpellier], Boutin, Marion
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
[SDV]Life Sciences [q-bio]
viruses
lcsh:QR1-502
medicine.disease_cause
lcsh:Microbiology
MESH: Hepatitis E virus / classification
MESH: Genotype
0302 clinical medicine
Personal hygiene
Hepatitis E virus
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
MESH: Immunoglobulin M / blood
Epidemiology
Genotype
Prevalence
risk factors
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Yellow fever
MESH: Immunoglobulin G / blood
Age Factors
MESH: Hepatitis E virus / genetics
virus diseases
MESH: Hepatitis Antibodies / blood
Jaundice
Hepatitis E
3. Good health
[SDV] Life Sciences [q-bio]
Infectious Diseases
MESH: Young Adult
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
RNA
Viral
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
MESH: RNA
Viral / blood
epidemiology
medicine.symptom
Adult
medicine.medical_specialty
Adolescent
[SDV.IMM] Life Sciences [q-bio]/Immunology
030231 tropical medicine
hepatitis E virus
Article
Young Adult
03 medical and health sciences
Virology
parasitic diseases
Burkina Faso
medicine
Humans
Seroprevalence
Hepatitis Antibodies
Genotyping
MESH: Prevalence
MESH: Adolescent
MESH: Age Factors
MESH: Hepatitis E / epidemiology
MESH: Humans
business.industry
MESH: Jaundice / epidemiology
MESH: Burkina Faso / epidemiology
MESH: Adult
medicine.disease
MESH: Male
digestive system diseases
030104 developmental biology
Immunoglobulin M
Immunoglobulin G
MESH: Jaundice / etiology
business
MESH: Hepatitis E / pathology
MESH: Female
Zdroj: Viruses
Volume 11
Issue 6
Viruses, MDPI, 2019, 11 (6), pp.554. ⟨10.3390/v11060554⟩
Viruses, 2019, 11 (6), pp.554. ⟨10.3390/v11060554⟩
Viruses, Vol 11, Iss 6, p 554 (2019)
ISSN: 1999-4915
DOI: 10.3390/v11060554
Popis: International audience; Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained markers of acute HEV infection (anti-HEV IgM and HEV RNA positive). Genotyping indicated that 14 of the strains were HEV genotype 2b. There was an overall HEV IgG seroprevalence of 18.2% (164/900). In a bivariate analysis, the factors linked to HEV exposure were climate and patient age. Older patients and those living in arid regions were more likely to have HEV infection. HEV genotype 2b circulating only in humans can be involved in some acute febrile icterus cases in Burkina Faso. Better access to safe water, sanitation, and improved personal hygiene should improve control of HEV infection in this country.
Databáze: OpenAIRE
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