Injectable Scaffold-Systems for the Regeneration of Spinal Cord: Advances of the Past Decade
| Autor: | Antonella Motta, Claudio Migliaresi, Sofia Santi, Ilaria Corridori, Nicola M. Pugno |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Percutaneous 0206 medical engineering Biomedical Engineering 02 engineering and technology Injections Biomaterials Lesion Spine surgery In vivo medicine Humans Spinal cord injury Spinal Cord Injuries Tissue Scaffolds business.industry Regeneration (biology) 021001 nanoscience & nanotechnology Spinal cord medicine.disease 020601 biomedical engineering Surgery medicine.anatomical_structure Injectable scaffold medicine.symptom 0210 nano-technology business |
| Zdroj: | ACS Biomaterials Science & Engineering. 7:983-999 |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.0c01779 |
| Popis: | Nowadays, whenever is possible and as an alternative to open spine surgery, minimally invasive procedures are preferred to treat spinal cord injuries (SCI), with percutaneous injections or small incisions, that are faster, less traumatic, and require less recovery time. Injectable repair systems are based on materials that can be injected in the lesion site, can eventually be loaded with drugs or even cells, and act as scaffolds for the lesion repair. The review analyzes papers written from 2010 onward on injectable materials/systems used/proposed for the regenerative and combinatorial therapies of SCI and discusses the in vivo models that have been used to validate them. |
| Databáze: | OpenAIRE |
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