Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population
| Autor: | Muthukrishnan Eaaswarkhanth, Mohammed Dashti, Hussain Alsaleh, Juan L. Rodriguez-Flores, Fahd Al-Mulla, Thangavel Alphonse Thanaraj |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Science Population DNA Mitochondrial Polymorphism Single Nucleotide Haplogroup Article White People Fat mass Asian People Genetics Medicine Humans Genetic Predisposition to Disease Obesity Risk factor education Qatar Exome sequencing education.field_of_study Multidisciplinary business.industry nutritional and metabolic diseases Odds ratio Middle Aged medicine.disease Computational biology and bioinformatics Mitochondria Haplotypes Genome Mitochondrial Female business Demography Human mitochondrial DNA haplogroup |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Obesity, a major risk factor for metabolic disorders, is highly prevalent in Qatari population. Maternal transmission of obesity traits can be significant; for example, X haplogroup is known to be associated with lower BMI and body fat mass in Northern Europeans and T haplogroup which is a sister haplogroup of J is known to be associated with obesity in Caucasian subjects from Austria and Southern Italy. We aimed to delineate the mitochondrial haplogroups and variants associated with obesity in Qatari population. Mitochondrial genomes of 864 Qatari individuals were extracted from whole exome sequencing data with an average coverage of 77X. We distributed the participants into 2 sub-cohorts: obese (BMI ≥ 30) and non-obese (BMI P = 0.0038; the Bonferroni adjusted P value threshold is 0.0041), whereas the individuals with haplogroup X were at low risk of obesity (OR 0.387; 95% CI 0.175–0.857; P = 0.019). Further, a set of 38 mitochondrial variants were found to be associated (at P ≤ 0.05) with obesity in models adjusted for age, sex and haplogroup. |
| Databáze: | OpenAIRE |
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