Transcranial direct-current stimulation enhances implicit motor sequence learning in persons with Parkinson's disease with mild cognitive impairment
| Autor: | Frank Van Overwalle, Natacha Deroost, Karlijn Van Herk, Eric Kerckhofs, Eva Swinnen, Chris Baeken, Mahyar Firouzi |
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| Přispěvatelé: | Physiotherapy, Human Physiology and Anatomy, Doctoraatsbegeleiding, Psychology, Faculty of Physical Education and Physical Therapy, Rehabilitation Research, Brain, Body and Cognition, Clinical sciences, Neuroprotection & Neuromodulation, Psychiatry |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Serial reaction time
Male medicine.medical_specialty Parkinson's disease Cognitive Neuroscience medicine.medical_treatment Behavioral neuroscience Audiology Transcranial Direct Current Stimulation 050105 experimental psychology Procedural memory 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Statistical significance medicine Reaction Time Dementia Humans 0501 psychology and cognitive sciences Cognitive Dysfunction Aged Transcranial direct-current stimulation 05 social sciences Motor Cortex Parkinson Disease medicine.disease Neuropsychology and Physiological Psychology Female Primary motor cortex Psychology human activities 030217 neurology & neurosurgery |
| Popis: | Implicit motor sequence learning (IMSL) is affected in Parkinson's disease (PD). Research in healthy young participants shows the potential for transcranial direct-current stimulation (tDCS) over the primary motor cortex (M1) to enhance IMSL. In PD, only null effects have been reported to date. We determined concurrent, short-term, and long-term effects of anodal tDCS over M1 on IMSL, as measured by the serial reaction time (SRT) task, in persons with PD with mild cognitive impairment (MCI). Concurrent (anodal/sham tDCS intervention during the SRT task), short-term (5 min post-intervention), and long-term (1 week post-intervention) effects on IMSL were evaluated in persons with idiopathic PD (Hoehn and Yahr stage II-III) with MCI. Results of 11 persons with PD (8 men and 3 women; mean age = 77.1 years; mean disease duration = 7.7 years) showed significant IMSL in the anodal (p = .016), but not in the sham tDCS condition (p = .937). Post-hoc analyses showed that IMSL reached statistical significance at 1 week post-intervention (p < .001). Anodal tDCS over M1 exerted beneficial effects on IMSL in persons with PD with MCI, in particular one week post-intervention. Our study is the first to report a positive effect of tDCS on IMSL in PD. Further research should include a larger, more cognitively diverse sample and additional follow-up periods. |
| Databáze: | OpenAIRE |
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