The Effect of Carnitine Supplementation on Blood Ammonia Level in Epilepsy Children Treated with Valproic Acid: A Randomized Controlled Trial
| Autor: | I Gusti Ngurah Made Suwarba, Dyah Kanya Wati, Ida Bagus Subanada, I Gusti Lanang Sidiartha |
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| Rok vydání: | 2021 |
| Předmět: |
Valproic Acid
Average duration medicine.medical_specialty business.industry Mean age medicine.disease Gastroenterology law.invention lcsh:Biochemistry Epilepsy Randomized controlled trial law Internal medicine lcsh:Pathology medicine lcsh:QD415-436 Blood ammonia Carnitine business lcsh:RB1-214 medicine.drug Blood ammonia level |
| Zdroj: | MCBS (Molecular and Cellular Biomedical Sciences), Vol 5, Iss 1, Pp 18-21 (2021) |
| ISSN: | 2527-3442 2527-4384 |
| DOI: | 10.21705/mcbs.v5i1.177 |
| Popis: | Background: Long-term use of valproic acid is associated with a high level of blood ammonia related to carnitine deficiency. This study investigates the effect of carnitine supplementation on blood ammonia levels in children with epilepsy who have been treated with valproic acid for more than six months. Materials and Methods: This was a randomized, double-blind, placebo-controlled trial study where children with epilepsy who were treated with valproic acid were randomly allocated to the carnitine supplementation and control group. All children were followed for month, and then measured for blood ammonia level. Blood ammonia levels of both groups were compared using an Independent t-test with a significant of p |
| Databáze: | OpenAIRE |
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