What is the significance of interictal water diffusion changes in frontal lobe epilepsies?
| Autor: | Maxime Guye, Patrick Chauvel, Sylviane Confort-Gouny, Patrick J. Cozzone, Fabrice Bartolomei, Aileen McGonigal, Jean-Philippe Ranjeva, Jean Régis |
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| Přispěvatelé: | Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Epilepsies, Lesions Cerebrales et Systemes Neuraux de la Cognition, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male [SPI.OTHER]Engineering Sciences [physics]/Other Statistical mapping analysis medicine.medical_specialty Adolescent Epilepsy Frontal Lobe Cognitive Neuroscience Frontal lobe epilepsy Stereo-electro-encephalography 030218 nuclear medicine & medical imaging Diffusion 03 medical and health sciences Epilepsy 0302 clinical medicine Body Water Seizures Internal medicine Image Processing Computer-Assisted medicine Humans Ictal Water diffusion Brain Mapping Seizure frequency Frontal Lobe Epilepsies Statistical mapping Electroencephalography Epileptogenic zone medicine.disease Electrophysiology Diffusion imaging Diffusion Magnetic Resonance Imaging Neurology Frontal lobe Cardiology Female Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Europe PubMed Central NeuroImage NeuroImage, Elsevier, 2007, 35 (1), pp.28-37. ⟨10.1016/j.neuroimage.2006.11.049⟩ NeuroImage, 2007, 35 (1), pp.28-37. ⟨10.1016/j.neuroimage.2006.11.049⟩ |
| ISSN: | 1053-8119 1095-9572 |
| DOI: | 10.1016/j.neuroimage.2006.11.049 |
| Popis: | International audience; The aim of this study was to better understand the significance of interictal changes in water molecule diffusivity defined by diffusion-weighted imaging (DWI) in frontal lobe epilepsy (FLE), as well as to test the accuracy of interictal DWI in the definition of the epileptogenic zone (EZ).DWI was carried out in 14 patients with refractory FLE (9 negative-MRI) as well as in 25 controls. Statistical mapping analysis (SPM2) of diffusivity maps was used to detect, for each subject, significant diffusivity alterations. We then studied the relationships between diffusion and depth recorded electrical abnormalities. Clinical correlates of the extent of diffusivity changes were also tested. We found areas of significantly increased diffusivity (SID) in 13 patients. Eight had SID in the EZ, 9 within the irritative zone (IZ) and 12 outside, mainly in connected areas. We found a correlation between the extent of SID and the duration of epilepsy (p corrected = 0.026, R = 0.621). In addition, SID was significantly less widespread in negative-MRI patients (p = 0.028). However, we found no significant differences concerning either seizure frequency (p = 0.302), seizure generalization (p = 0.841), history of status (p = 0.396), or surgical outcome (p = 0.606). We suggest that SID in normal appearing areas is not a specific signature of epileptogenicity in FLE, and is more likely to reflect multifactorial and potentially evolving neuro-glial injuries. |
| Databáze: | OpenAIRE |
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